Rimantadine hydrochloride amethyl1adamantanemethylamine hydrochloride

A derivative of amantadine hydrochlo-ride licensed as an antiviral agent. Good results have been reported from its use in the treatment of patients with Influenza virus A infections. Toxic effects include anxiety, nightmares and vomiting, but are less than with amantadine.

Galegov GA et al (1979) Lancet i, 269

Rinderpest virus (RPV) A species in the genus Morbillivirus. A serious natural infection of wild and domestic animals in many parts of Asia and Africa. Ox, zebu, buffalo, yak, sheep, goats, pigs, camels, hippopotamus, warthog, giraffe and several other wild animals are naturally infected. In the acute disease there is high fever and constipation followed by diarrhea. Mortality may exceed 90%. Inflammation and ulceration of the whole alimentary tract is the main pathological lesion, but patchy pneumonia may occur. Transmission is by direct contact and outbreaks usually start by the introduction of an infected animal with up to 100% infection of the affected herd. Control is by slaughter and use of tissue-culture-attenuated vaccines, which generate life-long immunity. The virus is closely similar in structure to Measles and Canine distemper virus and contains cross-reacting antigens. Serum from rinderpest virus-infected cattle prevents hemagglu-tination by Measles virus. Several live virus-attenuated vaccines are available and a global rinderpest eradication campaign coordinated by the Food and Agriculture Organization of the United Nations (FAO) is underway. Synonyms: cattle plague virus; peste bovina; peste bovine.

Barrett T (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 1559

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