RING finger motif See RING finger proteins

RING finger proteins Proteins having a sequence related to the zinc finger but containing additional cysteine and histi-dine residues that help the molecule to form a ring. Play a critical role in mediating the transfer of ubiquitin both to heterologous substrates and to the RING finger proteins themselves. Ubiquitina-tion is a first step in protein degradation, and some viruses, notably Human papillomavirus, express ring finger proteins that cause ubiquitination leading to degradation of cellular proteins, such as p53.

Freemont PS (2000) Curr Biol 10, R84 Joazeiro CAP and Weissman AM (2000) Cell 102, 549

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