S23dihydroxypropyladenine An

antiviral agent which inhibits rotavirus infection.

Smee DF et al (1982) Antimicrob Ag Chemother 21, 66

adenine arabinoside 9-P-D-Arabinofurano-syladenine. An antiviral agent. Synthesized in 1960, it was subsequently found as a naturally occurring nucleoside in culture filtrates of Streptomyces antibioticus. Phosphorylated to the active form, araATP, by cellular kinases it inhibits viral DNA synthesis at lower concentrations than are required to inhibit host cell DNA synthesis, by inhibiting the viral DNA polymerase. It neither directly inactivates virus nor prevents attachment. In the body it is speedily converted to the hypoxanthine, with a decline to less than 50% of the original antiviral activity. It is active against herpesvirus and poxvirus; less so against adenovirus and papovavirus. The drug has no action against RNA viruses. Although acyclovir is the drug of choice for treatment of herpes simplex or varicella-zoster infections, adenine arabinoside appears useful for treatment of acyclovir-resistant mutant viruses. Synonyms: vidarabine; araA; vira-A.

Whitley RJ et al (1980) Drugs 20, 267

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