Stomatitispneumoenteritis complex virus

Synonym for Peste des petits ruminants virus.

stop codon The trinucleotide sequence at which protein synthesis is terminated. There are three stop codons: UAA (Ochre), UAG (Amber) and UGA (Opal). There is evidence that UGA may signal the insertion of selenocysteine in some contexts, especially in HIV replication. See suppressor. Synonym: nonsense codon.

Brenner S et al (1961) Nature 190, 576 Taylor EW (1994) J Med Chem 37, 2637

Stoxil Trade name for idoxuridine eye drops.

strain An isolate of a virus which resembles the type virus in the major properties that define the type, but differs in minor properties such as vector species specificity, symptoms induced, serological and genetic properties. In practice, it is often very difficult to differentiate the boundaries between variants, strains and species of viruses. In the past antigenic cross-reactivity (serotyping) was the main means of distinguishing closely related viruses. With the advent of PCR and sequence analysis, relationships between viruses as determined by genome sequence comparison is considered the most appropriate way to decide upon species and strains. See serotype.

strand polarity The organization of the nucleotide sequence in a single-stranded nucleic acid. Positive (+) polarity refers to single-stranded molecules that contain the same sequence as mRNA. Negative (-) polarity molecules have sequence complementary to the (+)-sense strand.

Stratford virus (STRV) A strain of Kokobera virus in the genus Flavivirus, belonging to the Japanese encephalitis virus group. Isolated from Aedes vigilax in Queensland,

Australia. Not reported to cause disease in humans or other animals.

street virus A virulent wild strain. A term applied to rabies virus isolated from animals. After attenuation through passage in rabbits, the virus is called 'fixed virus'.

streptavidin A protein which binds to biotin. When coupled to an enzyme such as horseradish peroxidase, it will detect biotin in biotinylated DNA so providing a non-radioactive detection technique for specific sequences.

Hiller Y (1987) Biochem J 248,167

streptovitacin A A glutarimide antibiotic. A potent reversible inhibitor of protein synthesis.

stress proteins A small group of cellular proteins that are synthesized in response to metabolic stress including heat-shock. Viral infection often suppresses the synthesis of host cell proteins, but the stress protein genes, along with the genes encoding interferon proteins, are generally activated by virus infection.

Jindal S and Malkovsky M (1994) Trends Microbiol 2, 89

strigid herpesvirus 1 (StHV-1) An unas-signed virus in the family Herpesviridae. Isolated from owls of several species in which it may cause hepatosplenitis and paralysis. Disease can be produced experimentally in owls but not other birds. Replicates on the CAM and in the allantois.

Synonym: owl hepatosplenitis herpesvirus.

Burtscher H and Sibalin M (1975) J Wildl Dis 11, 164

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