Tetraonine endogenous retrovirus TERV

A probable species in the genus Alpharetrovirus, identified by RT-PCR sequence analysis of the genome of a ruffled grouse, Bonasa umbellus. Analysis of the complete proviral DNA sequence showed that it occurred in Tetraoninae (grouse and ptarmigan) but not in other subfamilies of galliform birds such as chickens or ducks.

Dimcheff DE et al (2001) J Virol 75, 2002

Tettnang virus Thought to be an arbovirus but now identified as a strain of mouse hepatitis virus, probably originating from the mice used for isolation.

Bardos V et al (1980) Intervirology 13, 275

TH-1, subline B1 cells (CCL 50) A ter-rapene heart line established from the trypsinized heart of a box turtle.

Thailand virus (THAIV) A species in the genus Hantavirus. Strain Thai 605 was isolated from Rattus norvegicus and strain 749 from Bandicota indica, in Thailand. Human infections have been detected serologically.

Elwell MR et al (1985) SE Asian J Trop Med Publ Hlth 16,349

Thcar virus A strain of Tembusu virus in the genus Flavivirus, isolated in Northern Thailand.

Theilovirus (ThV) A species in the genus Cardiovirus. The RNA genome lacks a poly C tract, in contrast to other species in the genus. A common and usually inapparent infection of laboratory and wild rodents. Occasional animals develop flaccid paralysis of the hind limbs. In the 1930s Theiler showed that injection of mice i.c. may produce flaccid paralysis after 12-29 days. Mice injected with the virus and recovering may later develop demyelinating disease. Mice from a colony free of infection respond more regularly to experimental infection. Replicates in mouse kidney cell cultures and, after adaptation, produces CPE. Strains vary in the cells in which they will replicate. There are several strains: BeAn,

DA, TO, FA, and GD I-VII; FA and GD VII on i.m. injection produce local myosi-tis in mice. FA causes encephalitis. The BeAn and DA strains are less virulent and produce persistent infections with chronic demyelination. FA and GD VII are antigenically related. The virus has been purified and its crystallographic structure determined. Synonyms: mouse poliovirus; murine poliovirus; mouse encephalomyelitis virus; polio-encephalomyelopathy; Theiler's murine encephalomyelitis virus; Theiler's virus.

Lipton HL (1999) In Encyclopedia of Virology, Second edition, edited by A Granoff and RG Webster. London: Academic Press, p. 1773 Monteyne P et al (1997) Immunol Rev 159, 163

therapeutic index The ratio of the median lethal dose of a drug to the median effective dose.

Thetalymphocryptovirus A name proposed but not so far adopted for a genus in the family Herpesviridae. It would contain Gallid herpesvirus 2 (Marek's disease virus) as its type species and Meleagrid herpesvirus 1 as a second member.

Thiafora virus (TFAV) A species in the genus Nairovirus. With Erve virus forms the Thiafora serogroup. Isolated from the shrew, Crocidura sp, in Senegal. Has also been isolated in Cameroon.

Institut Pasteur, Dakar (1977) Annual Report. Reference Center on Arboviruses 6

thick leg disease virus Synonym for osteopetrosis virus, a strain of Avian leukosis virus.

Thimiri virus (THIV) A species in the genus Bunyavirus, belonging to the Simbu serogroup. Isolated from the pond heron or paddybird, Ardeola grayii, in Tamil Nadu, India and from the lesser white-throat, Sylvia curruca, in Egypt. Not reported to cause disease in humans.

Thogotovirus A genus in the family Orthomyxoviridae of which Thogoto virus is the type species The other species in the genus is Dhori virus. Virions contain six (THOV) or seven (DHOV) segments of linear negative-strand RNA, with a total genome size about 10 kb. The conserved sequences of the RNA segments are reminiscent of those found in the genome segments of influenza virus. A virus closely related genetically to Dhori virus is Batken virus, isolated from mosquitoes and ticks from Russia.

Thogoto virus (THOV) A species in the genus Thogotovirus. Virions contain six segments of linear negative-strand single-stranded RNA. Total genome 10kb in length. Sequences at the ends of each segment resemble those of influenza virus. Isolated from humans, cattle, camels and from ticks of Boophilus and Rhipicephalus sp in Egypt, Kenya, Nigeria and Sicily. Antibodies present in sheep, goats, cattle and camels. Causes disease in humans, sometimes severe. Optic neuritis and meningoencephalitis are reported.

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