Anti Lselectin antibody did not overcome unresponsive state of T cells induced by superantigen

It is essential for homeostasis of the immune system to maintain the peripheral tolerance. T cell inactivation, in which T cells exhibit only weak responses on antigenic stimulation as to impaired IL-2-production and proliferation, is called anergy and recognized as one of the mechanisms to downregulate immune responses.15 We used SEB-induced anergy as a model system of unresponsiveness induced in vivo. Although MEL14 significantly enhanced the proliferation of responding T cells obtained from PBS-injected mice, the proliferation of unresponsive T cells from SEB-injected mice was not induced by the in vitro stimulation of SEB even in the presence of MEL14 (Fig. 2). This result indicates that signaling via L-selectin does not rescue the unresponsiveness of T cells.

0 0.04 0.2 1 5 Concentration of MEL14 C/i i/ml)

0 0.04 0.2 1 5 Concentration of MEL14 C/i i/ml)

Figure 2. Proliferation assay of the SEB-induced unresponsive T cells.

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