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Preface xi

Symposium

MESENCHYMAL CELLS: METALLOPROTEINASES AND ADHESION ON MICROCARRIERS

C. Mosbeux, A. R. dos Santos Pedregal, D. Ribeiro de Sousa, Vincianne Hendric, N. Joseph, M. Bensellam, D. Blankaert, T. Marique, C. Alloin, D. Parent, C. Liesnard, J. P. Van Vooren,

CHARACTERIZATION OF PEANUT SPECIFIC T CELLS

USING METABOLOMICS TO BETTER UNDERSTAND FUNCTIONAL FOODS

Dayan B. Goodnowe, Yasuyo Yamazaki, and

Bernhard H. J. Juurlink 21

FOOD FACTORS THAT REGULATE INTESTINAL INFLAMMATION: EVALUATION OF THE FACTORS BY USING A COCULTURE SYSTEM

Hideo Satsu, and Makoto Shimizu 29

GENERATION OF AN INDUSTRIALLY IDEAL HOST CELL

LINE FOR PRODUCING COMPLETELY-DEFUCOSYLATED ANTIBODY

WITH ENHANCED ANTIBODY-DEPENDENT

CELLULAR CYTOTOXICITY (ADCC)

Mitsuo Satoh, Naoko Yamane-Ohnuki, Katsuhiro Mori, Ripei Niwa, Toyohide Shinkawa, Harue Imai, Reiko Kuni-Kamochi, Ryosuke Nakano, Kazuya Yamano, Yutaka Kanda, Shigeru Iida, Kazuhisa Uchida, and Kenya Shitara 39

THERMODYNAMIC AND KINETIC EFFECTS OF HUMAN IgG1 DEFUCOSYLATION ON IgG1-FcyRIIIa INTERACTION

Akira Okazaki, Emi Shoji, Kazuyasu Nakamura, Masako Wakitani,

Kazuhisa Uchida, Shingo Kakita, Kouhei Tsumoto, Izumi Kumagai, and Kenya Shitara 47

Oral Session

EXPRESSION OF RECOMBINANT PROTEIN IN CHO AND HELA CELLS AND ITS FOLLOW-UP USING EGF REPORTER GENE

V. Hendrick, D. Ribeiro de Sousa, A. R. dos Santos Pedregal , C. Bassens,

ELUCIDATING APOPTOTIC CELL DEATH IN CHO CELL BATCH & FED-BATCH CULTURES

Danny C. F. Wong, C. K. Danny C. F. Wong, C. K. Heng,

Kathy T. K. Wong, Peter M. Nissom, and Miranda G. S. Yap 61

THE X-LINK INHIBITOR OF APOPTOSIS PROTEIN (XIAP) ENHANCES THE SURVIVABILITY OF C2E7 HYBRIDOMA CELLS UNDER A SERUM DEPRIVED CONDITION

TRANSCRIPTIONAL PROFILING OF BATCH AND FED-BATCH PROTEIN-FREE 293-HEK CULTURES USING DNA MICROARRAY

Yih Yean Lee, Kathy Wong, Peter Morin Nissom, and

Miranda G. S. Yap 73

STUDIES ON THE EFFICACY, SAFETY AND QUALITY OF THE TISSUE ENGINEERED PRODUCTS: ENHANCEMENT OF PROLIFERATION OF HUMAN MESENCHYMAL STEM CELLS BY THE NEW POLYSACCHARIDES

Saifuddin Ahmed, Toshie Tsuchiya, and Yutaka Kariya 81

STUDIES ON THE EFFICACY, SAFETY AND QUALITY OF THE TISSUE ENGINEERED PRODUCTS: EFFECTS OF A CATALYST USED IN THE SYNTHESIS OF BIODEGRADABLE POLYMER ON THE CHONDROGENESIS OF HUMAN ARTICULAR CARTILAGE

Nasreen Banu, Toshie Tsuchiya, Saifuddin Ahmed, and

Rumi Sawada 87

THE ROLE OF BIFIDOBACTERIUM IN THE DEVELOPMENT OF GUT IMMUNE SYSTEMS: ANALYSIS USING GNOTOBIOTIC TCR-TRANSGENIC MICE

Masato Tsuda, Akira Hosono, Miran Fujioka, Satoshi Hachimura, Ryo Nakamura, Kazuhiro Hirayama, Kikuji Itoh, and

Shuichi Kaminogawa 93

THE ROLE OF CD4+ T CELLS IN IgA PRODUCTION IN MURINE PEYER'S PATCHES FOLLOWING ORAL FEEDING OF BIFIDOBACTERIUM COMPONENTS

Yusuke Nakanishi, Akira Hosono, Teiji Kimura, and

Shuichi Kaminogawa 101

SUPPLEMENTATION OF SERICIN IS EFFECTIVE IN MAINTENANCE OF ISLET SURVIVAL AND FUNCTION UNDER SERUM-FREE CULTURE

Akiko Ogawa, Satoshi Terada, Masao Miki, Toshihisa Kimura,

Akio Yamaguchi, Masahiro Sasaki, and Hideyuki Yamada 107

SUPPRESSION OF TWO-STAGE CELL TRANSFORMATION BY ELECTROLYZED REDUCED WATER CONTAINING PLATINUM NANOPARTICLES

Ryuhei Nishikawa, Kiichiro Teruya, Yoshinori Katakura, Kazumichi Otsubo, Shinkatsu Morisawa, Qianghua Xu, and Sanetaka Shirahata 113

Poster Session

INFLUENCE OF BOTH GLUCOSE AND GLUTAMINE CONCENTRATION ON MAB PRODUCTION RATE IN CHEMOSTAT CULTURE OF CHO CELLS

Hiroshi Matsuoka, Jun-ya Watanabe, and Toshiya Takeda 121

INTRODUCTION OF GENES RELATING TO MUSCULAR DYSTROPHY INTO CHIMERIC CHICKENS BY EMBRYO ENGINEERING

Akira Fujiwara, Makoto Mizutani, Tamao Ono, and

Hiroshi Kagami 127

PLURIPOTENT CELL CULTURE ENGINEERING AND THE APPLICATION FOR AVIAN BIOTECHNOLOGY Hiroshi Kagami, Tomoki Mushika, Takamasa Noguchi, Yasuhiro Yamamoto, Akira Fujiwara, Naomi Yamakawa,

Hisato Okuizumi, and Tamao Ono 135

EFFECT OF OXYGEN TENSION ON THE PROLIFERATION AND THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS

ENHANCEMENT OF ANTIBODY PRODUCTION BY ADDITION OF UBIQUINONE-Q10

Yoshinobu Konno, Motoi Aoki, Masakazu Takagishi,

Hiroshi Takasugi, Masamichi Koike, and Shinji Hosoi 149

OBSERVATION OF INDIVIDUAL CELL BEHAVIORS TO ANALYZE MITOGENIC EFFECTS OF SERICIN

Tomohiro Toyosawa, Satoshi Terada, Masahiro Sasaki,

Hideyuki Yamada, and Masahiro Kino-oka 155

STUDIES OF PASSAGE EFFECT OF HaNPV BACULOVIRUS PRODUCED IN Hz INSECT CELL CULTURE

Kanokwan Poomputsa, Kultida Poltawee, Somkiet Techkarnjanarak, and Phenjun Mekvichitsaeng 163

OPTIMIZATION OF RECOMBINANT DENGUE ENVELOPE PROTEIN PRODUCTION IN INSECT CELL CULTURE IN 2.5 L FERMENTER

Phenjun Mekvichitsaeng, Somsak Sotasan, and Kanokwan Poomputsa ... 169 TARGETED DISRUPTION OF a-1, 6-FUCOSYLTRANSFERASE (FUT8) GENE BY HOMOLOGOUS RECOMBINATION IN CHINESE HAMSTER OVARY (CHO) CELLS

Masayoshi Tsukahara, Ayako Aoki, Keina Kozono, Yoko Maseki,

Yukiko Fukuda, Hideaki Yoshida, Kazuo Kobayashi,

Makoto Kakitani, Kazuma Tomizuka, and Haruhiko Tsumura 175

IMMUNOSTIMULATION EFFECT OF THE FERMENTED MILK ON HUMAN HYBRIDOMAS AND PERIPHERAL BLOOD LYMPHOCYTES

Takuya Sugahara, Katsunori Nakamoto, andKazushi Hara 185

TRACE ELEMENT OPTIMIZATION ENHANCES PERFORMANCE AND REPRODUCIBILITY OF SERUM-FREE MEDIUM

Scott J. Jacobia, Robert W. Kenerson, Lia D. Tescione, Dale F. Gruber, David W. Jayme, Donald G. Munroe, and Stephen F. Gorfien 193

PHENOMENOME PROFILERâ„¢ ANALYSIS OF HUMAN COLON CANCER CELL LINES

Yasuyo Yamazaki, Shawn Ritchie, and Yanqiu Jiang 201

GENERATION OF NATURAL KILLER CELLS FROM SERUM-FREE EXPANDED CD34+ CELLS ISOLATED FROM HUMAN UMBILICAL CORD BLOOD

I-TingKao, Zwe-Ling Kong, Mei-Ling Wu, Li-Wen Hsu,

Chao-Ling Yao, and Shiaw-Min Hwang 211

RETINOIC ACID IMPROVES CELL PROLIFERATION AND ANTIBODY PRODUCTION OF HUMAN HYBRIDOMAS NONPROLIFERATIVE IN A FRUCTOSE-BASED MEDIUM

Yuichi Inoue, Sanetaka Shirahata, and Yasushi Sugimoto 219

CONSTRUCTION OF RECOMBINANT MONOCLONAL ANTIBODY AGAINST HEPATITIS B SURFACE ANTIGEN BY PHAGE DISPLAY

Apichai Prachasuphap, Chaivat Kittigul, Patcharee Sunthoranandh,

Panadda Dhepakson, Nongluk Buddhirakkul, and

Kruavon Balachandra 227

A HUMAN CATALYTIC ANTIBODY WITH THE LIGHT CHAIN RAISED BY SECONDARY VJ RECOMBINATION IN A HUMAN PLASMA CELL LINE

Minoru Iwaki, Hirofumi Tachibana, Ryuichi Sakamoto, andKoji Yamada 233

17BETA-ESTRADIOL REGULATES IMMUNOGLOBULIN M PRODUCTION THROUGH INTERACTION WITH ESTROGEN RECEPTORS

Mako Nakaya, Hirofumi Tachibana, and Koji Yamada 239

MDCK CELLS RESISTANT TO METALLOPROTEINASE FROM STREPTOMYCES GRISEUS ACQUIRE ANCHORAGE INDEPENDENT SURVIVAL AND PROLIFERATION ABILITIES ON NON ADHESIVE SUBSTRATE

Reiko Tsutsumi, Masanori Shozushima, and Shigehiro Sato 247

THE IMMUNE RESPONSES OF THE PRIME-BOOST REGIMEN WITH rBCG-E12 AND rDIs-E12 CANDIDATE VACCINE

P Leangaramgul, S. Sapsutthipas, K. Balachandra, K. Matsuo,

T. Hamano, and M. Honda 255

INCREASE IN THE INSULIN SECRETION OF HIT-T15 CELLS: GAP JUNCTIONAL INTERCELLULAR COMMUNICATIONS ENHANCED BY HYALURONIC ACID

Yuping Li, Tsutomu Nagira, and Toshie Tsuchiya 263

CULTURE OF INSULINOMA CELLS ON PANCREAS SECTION

Yasuyuki Saito, Satoshi Terada, and Toshiaki Takezawa 271

DOWNREGULATION OF a5 p1INTEGRIN EXPRESSION DURING NEURONAL DIFFERENTIATION IN NEURAL STEM CELLS

Dai Muramatsu, Noko Yoshida, Sohei Hishiyama,

Yasei Miyamoto, and Tatsuhiro Hisatsune 277

STRATEGIES FOR DEVELOPMENT OF CULTURE MEDIA: APPLICATION TO EMBRYONIC AND ADULT STEM CELLS Shayne Boucher, Paul Price, Ian Lyons, John Daley and David Jayme 285

PREPARATION OF HIGH-TITER RETROVIRAL VECTORS USING TRANSIENT EXPRESSION SYSTEM Akitsu Hotta, Yoshikazu Saito, Ken-ichi Nishijima,

Msamichi Kamihira, and Shinji Iijima 293

BIOCHEMICAL ANALYSIS OF CHICKEN OVALBUMIN PROMOTER

Mahboob Morshed, Junko Yamamoto, Shusuke Sano,

Ken-Ichi Nishijima, Masamichi Kamihira, and Shinji Iijima 301

PRODUCTION OF CHIMERIC ANTIBODIES BY TRANSGENIC CHICKEN BIOREACTORS

Yoshinori Kawabe, Akitsu Hotta, Ken-Ichiro Ono, Kazuhisa Esaka,

Ken-Ichi Nishijima, Masamichi Kamihira, and Shinji Iijima 309

DETERMINATION OF THE MAJOR FOOD ALLERGEN, OVOMUCOID, WITH AN OLIGOCLONAL ENZYME-LINKED IMMUNOSORBENT ASSAY

Junko Hirose, Yukie Murakami-Yamaguchi, Miki Ikeda, and

Hiroshi Narita 317

SAFETY EVALUATION OF TISSUE ENGINEERED MEDICAL DEVICES USING NORMAL HUMAN MESENCHYMAL STEM CELLS

Rumi Sawada, Tomomi Ito, Yoshie Matsuda, and Toshie Tsuchiya 325

EFFECT OF BIODEGRADABLE POLYMER POLY (L-LACTIC ACID) ON THE CELLULAR FUNCTION OF HUMAN ASTROCYTES

Naohito Nakamura and Toshie Tsuchiya 331

IMMUNOLOGICAL ANALYSIS OF EPIDERMAL-TYPE TRANSGLUTAMINASE (TGase 3) IN EPITHELIUM

Kiyotaka Hitomi, Kanae Yamamoto, Koji Nishi, Yoshiaki Sugimura, andMasatoshi Maki 339

ANALYSIS OF INTERLEUKIN-6-INDUCED SIGNALING IN MURINE HYBRIDOMA CELL LINES

Kazuhiko Takemura, Tatuya Yamashita, and Satoshi Terada 347

IMMUNE REGULATION BY SIALOGLYCOCONJUGATE-BINDING LECTINS

Munetoshi Ando, Ken-ichi Nishijima, Shusuke Sano,

Aiko Hayashi-Ozawa, Yoshinori Kinoshita, and Shinji Iijima 353

TRANSCRIPTIONAL REGULATION OF THE a-FETOPROTEIN GENE IN HEPATOCYTES

Mikio Takahashi, Takeaki Dohda, Hidenori Kaneoka, Yoshitaka Sato, Yujin Inayoshi, Katsuhide Miyake,

Masamichi Kamihira, andShinji Iijima 361

MODULATION OF CYTOKINE AND IMMUNOGLOBLIN A RELEASE BY BETA-(1,3-1,6)-GLUCAN FROM AUREOBASIDIUMPULLULANS STRAIN 1A1

Takahiro Suzuki, Akira Hosono, Satoshi Hachimura,

Toshio Suzuki, and Shuichi Kaminogawa 369

INFLUENCE OF NATURAL REDUCED WATER ON RELEVANT TESTS PARAMETERS AND REACTIVE OXYGEN SPECIES CONCENTRATION IN BLOOD OF 320 DIABETES PATIENTS IN THE PROSPECTIVE OBSERVATION PROCEDURE

PROTEOME ANALYSIS OF NEURITE DIFFERENTIATION OF PHYTOESTROGEN-TREATED PC12 CELLS: PRELIMINARY RESULTS

Hiroko Isoda, Mariko Seki, Terence P. N. Talorete, and Junkyu Han 387

CAPSAICIN-ENHANCED RIBOSOMAL PROTEIN P2 EXPRESSION AND RECOVERY OF TIGHT JUNCTION PERMEABILITY IN HUMAN INTESTINAL CACO-2 CELLS Junkyu Han, Mitsuaki Akutsu, Terence P. N. Talorete,

Toshiyuki Tanaka, and Hiroko Isoda 395

METABOLIC RESPONSES OF EUKARYOTIC DRUG EFFICACY AND TOXICITY

D.B. Goodenowe, S. Ritchie, and D. Heath 403

SUPPRESSIVE EFFECT OF FUCOIDAN DERIVED FROM MOZUKU ON IN VITRO INVASION OF HUMAN FIBROSARCOMA HT1080 CELLS

Jun Ye, Kiichiro Teruya, Yoshinori Katakura,

Hiroshi Eto, and Sanetaka Shirahata 409

INCREASED EXPRESSION, PURIFICATION AND CHARACTERIZATION OF THE WW DOMAIN OF CA150/FBP28

Yusuke Kato, Yoriko Sawano, and Masaru Tanokura 417

IMPROVEMENT OF LIGATION-MEDIATED POLYMERASE CHAIN REACTION (LM-PCR) METHOD FOR GENOME WALKING WITH A SINGLE GENE-SPECIFIC PRIMER Keina Kozono, Ayako Aoki, Masayoshi Tsukahara, and Haruhiko Tsumura 425

Author Index 433

Subject Index 437

Preface

The 17th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT) was held at the Yagoto Mulberry Hotel in Nagoya, Japan from November 15 to 18, 2004. The meeting focused on the industrial applications of animal cell technology. We invited academic and industrial scientists from all over the world to participate and make the JAACT 2004 truly successful and scientifically fruitful. More than 330 participants from 20 countries joined the meeting and gave presentations (plenary lectures, 3; Murakami memorial lecture, 1; ESACT special lecture, 3; presentations by symposists, 37; technical seminars, 3; oral presentations, 33; poster presentations, 91). Fields and titles of 7 symposia were 1 "Process Development & Manufacturing on Biologics", 2. "Food Allergies -Current and Perspectives-", 3. "Evaluation of Anti-Inflammatory and Anti-Cancer Food Factors Using Animal Cell Culture Models", 4. Control and Production Change of Biopharmaceuticals, 5. "Recent Developments in the Small RNA World", 6. "Stem Cell Technology", 7. "Metabolomics as a powerful tool in postgenome era", 8. "Advanced Functional Water for Prevention of Diseases". All presentations (oral and poster) were brought together on the following themes.

1. Cell culture engineering

2. Production of biologicals

3. Functional cell lines

4. Glycoengineering

5. Immunologicals, monoclonal antibodies, and vaccines

6. Transplantation, artificial organs, and organ substitutes

7. Gene therapy

8. Transgenic animals

9. Safety and regulation

10. Cell regulatory factors and signal transduction

11. Functional substances in food and natural sources

12. Animal cells for in vitro assay

The editors hope this volume of Proceedings will greatly contribute to the development of animal cell technology or innovation of life science. The editors express their sincere gratitude to all the participants, organizers of the symposia, members of the organizing committee for their dedication in assuring the success of the meeting.

We also deeply thank to Nagoya Convention & Visitor Bureau, Daiko Foundation, Kato Memorial Bioscience Foundation and Research Foundation for the Electrotechnology of Chubu for their financial supports.

The editors xi

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