Procaine reaction

• This occurs when procaine benzylpenicillin is accidentally administered intravenously.

• Symptoms involve agitation, restlessness, disorientation, tachycardia, nausea, tremors, lethargy and hypotension.

• The toxic reaction is dose-related.

• The patient should be reassured that symptoms will resolve within 30-60 minutes of the administration of the drug.

• If there are any concerns about the patient, medical referral should be made.

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