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Allergy Relief

Allergy Relief

Have you ever wondered how to fight allergies? Here are some useful information on allergies and how to relief its effects. This is the most comprehensive report on allergy relief you will ever read.

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Allergy Relief

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Immunoglobulin EMediated Food Allergy Syndromes

Food allergies are often categorized for the organ systems they affect and by the immune mechanisms involved (Table 57-2) (Sicherer, 2002). Immune mediated reactions to food included immunoglobulin (Ig)E and sometimes IgG4-mediated responses that degranulate mast cells and Food allergy (immune-mediated mechanisms) basophils, so-called type I hypersensitivity. Other forms of food allergy can involve T cells, the generation of immune-complexes, and or the activation of eosinophils. Although the dermatologic and respiratory tract manifestations of food allergy are often better recognized, the GI tract can be affected by food allergies in various ways. IgE-mediated reactions to foods induce classic GI anaphylaxis in which food allergic reactions result in immediate hypersensitiv-ity within the GI tract resulting in nausea, vomiting, diarrhea, cramping, and abdominal pain. Isolated GI food allergy anaphylaxis is a relatively rare manifestation of food allergy, and, typically, the GI...

Tests for the Diagnosis and Management of Food Allergy

Methods to detect food-specific IgE including prick skin testing and measurements in blood are helpful in clinical practice but standardized tests to detect non-IgE mediated food allergy are not as well developed. Skin prick testing provides a readily available and relatively inexpensive means to assess a panel of food allergens in both children and adults. The major limitation of skin testing is its poor positive predictive value (many asymptomatic patients exhibit reactions to food allergens) but a negative test in the absence of antihistamine drugs strongly suggests that immediate hypersensitivity is an unlikely mechanism for the patient's food-induced complaints. Skin testing is not helpful in predicting who might outgrow their food allergies, and, in fact, skin reactivity to foods can persist without clinical manifestations while the individual goes on to develop inhalant allergies. Although quite widely used by various practitioners, sublingual challenge or neuro-muscular...

Prevention of Food Allergy

The optimum means to prevent the development of allergies in high risk individuals remains an area of controversy. Recommendations have been made in the United States and in Europe for infants with a strong family history of atopy at risk of developing food and other allergies and include the exclusive use of breastfeeding for at least 4 to 6 months, delayed introduction of solid foods until after 4 to 6 months of age, particularly allergenic foods such as egg, wheat, nuts, and fish, avoidance of all CMP, and if formula is needed, to use only extensively hydrolyzed or amino-acid based formulas. Partially hydrolyzed cow's milk, soy, and goat or sheep milk products are not recommended. Hypoallergenic diets have been recommended during pregnancy and with breastfeeding for atopic mothers to reduce the incidence of food allergy in their offspring. Probiotics offer another means to prevent the development of food allergy. The rationale for using probiotics in allergic diseases is that...

Treatment of Food Allergy

The cornerstone of the management of food allergy is avoidance of the offending allergen. This is particularly important in cases of peanut allergy where trace amounts of allergen can cause significant reactions. Most fatalities due to food allergy have been due to peanut allergy. Patients with food allergies should learn to read and understand labels for hidden food allergens and to recognize the potential for foods to cross-react with other antigens (eg, banana and kiwi with latex, and birch pollen with apple, carrot, and hazel nut). In North America the Food Allergy and Anaphylaxis Network (1-800-929-4040, <> ) is a source of valuable information for those with various types of food allergy. Similarly, it is important for celiac patients to join local celiac disease foundations and support groups that can provide valuable information used to determine sources of gluten free foods and medications. Infants with cow's milk protein allergy present a unique...

Extraoral Risks Allergy

Allergy to nickel is more common in extra-oral settings, most usually the headgear face bow or head strap. Over 1 of patients have some form of contact dermatitis to zips and buttons studs on clothing. Of these patients, 3 claim to have experienced a similar rash with orthodontic appliances (Fig. 12). The use of sticking plaster over the area in contact with the skin is sufficient to relieve symptoms. Allergy to latex27 and bonding materials has been reported although these are rare.

Newer Therapies for Food Allergy Biologic Therapy

Perhaps the most exciting developments in the field of food allergy are new therapeutic approaches that modulate immune responses to foods (Nowak-Wegrzyn, 2003). These include tolerogenic peptides, recombinant epitopes, anti-IgE and DNA vaccination, as well as administration of Th1 type cytokines, such as interleukin (IL)-12 and interferon , or strategies to antagonize the actions of Th2 cytokines, such as IL-4 and Il-5. The benefit of such approaches in food allergy was recently documented in a double blind randomized, placebo controlled, dose-ranging trial, in which a humanized monoclonal IgG1 antibody against IgE that recognizes and masks an epitope in the CH3 region of IgE responsible for binding to the FcReI on mast cells and basophils was administered subcutaneously in peanut allergic subjects (Leung et al, 2003). A statistically significant improvement (subjects increased their tolerance for peanuts from an average of 1.5 peanuts to 9 peanuts at one time) was seen between the...

Pollen Food Allergy Syndrome

The oral allergy syndrome or pollen-food allergy syndrome results from various plant proteins that cross-react with certain inhalant antigens, particularly birch, ragweed, and mug-wort (Sloane and Sheffer, 2001). Exposure to the cross-reacting foods may lead to pruritis, tingling and or swelling of the tongue, lips, palate, or oropharynx, and, occasionally, to bronchospasm or more systemic reactions. Foods that cross-react with birch include raw potatoes, carrots, celery, apples, pears, hazelnuts, and kiwi. Those individuals that are allergic to ragweed may react to fresh melons and to bananas. It is important to educate patients with inhalant allergies about potential cross-reacting foods.

Latex Food Allergy Syndrome

Latex-food allergy syndrome, also referred to as the latex-fruit syndrome, is a specific form of food allergy in which food antigens cross-react with various latex antigens (Blanco, 2003). Natural rubber latex contains over 200 proteins, 10 of which bind IgE Hevea brasiliensis latex protein allergens (HEV b 1 to 10) and cross-react with a variety of food antigens including kiwi (HEV b 5), potato and tomato (HEV b 7), and avocado, chestnut, and banana (HEV b 6). In latex-sensitive individuals exposure to these foods can result in the same symptoms as if exposed to latex ranging from pruritis, eczema, oral-facial swelling, asthma, GI complaints, and anaphylaxis. A large number of studies from around the world indicate that the natural rubber latex allergy is increasing in prevalence and that the frequency of associated food allergy varies from 21 to 58 (Blanco, 2003). Worldwide, banana, avocado, chestnut and kiwi are the most common causes of food-induced symptoms associated with latex...


Allergy to orthodontic components intra-orally is exceedingly rare, however, there have been studies on the nickel release and corrosion of metals with fixed appliances. Gjerdet et al.26 found a significant release of nickel and iron into the saliva of patients just after placement of fixed appliances. However, no significant difference was found in nickel or iron concentrations between controls and subjects where the appliances had been in place for a number of weeks. The clinical significance of nickel release is as yet unclear, but should be considered in nickel sensitive patients. There are a few cases with severe latex allergies who may be affected by elas-tomerics or operators gloves.

Allergic Reactions

Drugs or their reactive metabolites can cause an allergic reaction in patients that may be due to either cell-mediated or antibody-mediated reactions. There are various clinical manifestations of hypersensitivity reactions Allergy status must always be confirmed and recorded before the administration of any drug, and patients should be informed of any potential signs or symptoms to watch out for if they are at risk of an allergic reaction.

Preprocedure Evaluation

It is important to be familiar with sedation-oriented aspects of the patient's medical history, because this may affect the type of sedation administered. These include abnormalities of the major organ systems, previous personal or family adverse experience with sedation, drug allergies, current medications, and history of tobacco, alcohol, or substance use or

Tcell Prolifration In Response To Stimulation With Purified Ara H

That compared to the same T cells stimulated with CPE. CPE-specific T-cell lines could also be developed from normal individuals. However, the number of T-cell lines and the amplitude of the SI were greatly reduced when compared with those from peanut sensitive individuals (data not shown). These results indicate that in some individuals Ara h 2 represents the major allergenic protein found in CPE while in other patients it represents one of a number of different proteins that can stimulate T cells from peanut allergic individuals to proliferate.

Identification Of The Ara H 2 Tcell Epitopes

To understand food hypersensitivity reactions it is important to identify and characterize the protein allergens that are responsible for the immunologic disorder as well as the immunological responses. What is so different about the protein allergens that causes them to be recognized as pathogenic moieties by the immune system Why do peanut allergies persist throughout the life of an individual while allergies to similar proteins in other legumes such as soy are outgrown early in life Various proteins involved in hypersensitivity reactions to peanut have been identified (8, 9, 10, 11, 12), three of which have been cloned and characterized (Ara h 1, Ara h 2 and Ara h 3, 10, 11, and 12 respectively). Identification, isolation of the native Ara h 2 and characterization

Eczema and dermatitis

The terms eczema and dermatitis are interchangeable, covering a wide variety of conditions from the child with atopic eczema to the adult with an allergy to cement. If patients are told they have dermatitis they may assume that it is related to their employment with the implication that they may be eligible for compensation. It is not unusual for industrial workers to ask Is it dermatitis, doctor , meaning is it due to my job

Occupational dermatitis

In the workplace, all three factors may contribute to dermatitis. For example, a student nurse or trainee hairdresser is exposed to water, detergents, and other factors that will exacerbate any pre-existing eczema. In addition, there may be specific allergies and, as a result of the broken skin, secondary infection can occur making the situation even worse. The following points are helpful in determining the role of occupational causes. If secondary infection is present, this can keep a dermatitis active even when away from the workplace and sometimes allergen exposure continues at home for example, an allergy Whatever the cause of the dermatitis, the end result may seem the same clinically, because the inflammation and blisters of atopic eczema may be indistinguishable from an allergic reaction to rubber gloves. Generally, contact dermatitis is more common on the dorsal surface of the hands whereas atopic eczema occurs on the palms and sides of the fingers. Allergic contact...

Preoperative identification

Known history of anaphylaxis to latex. It does not always occur to patients that their rubber allergy might be of relevance to the anaesthetist. Two patients who denied allergies developed delayed responses of intraoperative hypotension and flushing. Both had increases in tryptase levels (10.4 mgl-1 and 8.5 mgl-1 normal 2 m gl-1), and positive skin prick tests to latex. Only at this stage did each patient declare their cutaneous reactions to latex (Fisher 1997).Another had hives after the use of gloves and sneezing during vaginal examinations (Ballantine & Brown 1995). She had undergone IVF for infertility, which involved regular use of a latex-covered vaginal probe. e) History of atopy, drugs allergies, food allergies such as bananas, kiwi fruit, and avocados.

Approach to Patients Complaining of ARF

A significant component of the difficulty in managing food allergy is determining whether the patient has food allergy or another form of ARF (Table 57-3). Guidelines for the evaluation of food allergies have recently been published as a medical position statement by the American Gastroenterological Association (Sampson et al, 2001). It is essential to obtain a careful history correlating symptoms with specific foods. Most immediate hypersensitivity reactions to food include a set of symptoms that consistently occur minutes to hours after ingesting certain foods. In some individuals, other factors, such as medications or exercise, may modulate the reaction to a specific food. Specificity of the reaction does not always imply a food allergy because patients with anaphylactoid reactions or lactose intolerance report defined reactions to specific foods. However, the nature of the reaction will help differentiate lactose intolerance (gas, bloating, diarrhea) from an allergy to cow's milk...

Other Immune Mediated GI Adverse Reactions to Food

Immunity (see Table 57-2), play a role in food protein-induced enterocolitis syndromes (FPIES), such as cow's milk protein enteropathy, and also celiac disease. FPIES also known as food protein-induced enteropathies, present in infancy or early childhood and are most commonly due to cow's milk protein followed by soy protein and less commonly, egg, fish, and other food antigens (Nowak-Wegrzyn et al, 2003). Clinical manifestations include diarrhea, vomiting, anemia, bleeding, and failure to thrive. As with many other food allergies, such cases are managed by elimination of the specific food antigen until the disease resolves with age. It is common practice to switch infants with enterocolitis from a cow's milk-based formula to a soy-protein derived formula, but because over half will react to soy protein, continued problems may result from the development of soy-protein-induced enterocolitis. Hypoallergenic or elemental feeds are often necessary in such cases.

Lawrence R SchillerMD

Most patients with gastrointestinal (GI) symptoms attribute their symptoms to something they ate and want advice from the doctor about what to eat to minimize their symptoms. Symptoms after food ingestion most often are due to normal food-induced physiological changes, such as the gastrocolic reflex, or to the effects of food digestion, such as the generation of gas. They rarely are due to food allergy or to immunologic reactions to food breakdown products, such as in celiac disease. Specific problems will not be discussed further in this chapter. There are separate chapters on food allergies (Chapter 57, Gastrointestinal Food Allergy), celiac disease (Chapter 61, Celiac Sprue and Related Problems), and lactose intolerance (Chapter 62, Lactose Intolerance).

Subsequent management

For management of further surgery, see Latex allergy (Section 1). D'Astous J, Drouin MA, Rhine E 1992 Intraoperative anaphylaxis secondary to allergy to latex in children who have spina bifida. Report of two cases. Journal of Bone & Joint Surgery 74 1084-6. Dakin MJ,Yentis SM 1998 Latex allergy a strategy for management.Anaesthesia 53 774-81. Fisher MMcD 1997 Latex allergy during anaesthesia cautionary tales.Anaesthesia & Intensive Care 25 302-3. Hodgson CA,Andersen BD 1994 Latex allergy an unfamiliar cause of intra-operative cardiovascular collapse.Anaesthesia 49 507-8. McKinstry LJ, Fenton WJ, Barrett P 1992 Anaesthesia in the patient with latex allergy. Canadian Journal ofAnaesthesia 39 587-9. Meehan PL, Galina MP, Daftari T 1992 Intraoperative anaphylaxis due to allergy to latex. Report of two cases. Journal of Bone & Joint Surgery 74A 1087-9. Sethna NF, Sockin SM, Holzman RS et al 1992 Latex allergy in a child with a history of multiple anesthetic drug...

Other causes of upper airways obstruction

Anaphylaxis is a potentially life-threatening immunologically mediated syndrome in which laryngeal oedema can develop over minutes often with swelling (angioneurotic oedema) of the face, mouth and tongue. Food allergies, especially nuts and drug reactions, especially contrast media and anaesthetic drugs are usual causes of this.

Other procedures carried out during resuscitation

History should be sought from the child, ambulance personnel, relatives, and witnesses of the accident. Ambulance staff should be able to provide a great deal of information, including details of the accident site and of pre-hospital care that was administered. Relatives should be able to give the child's past medical history and allergies, and provide details of the time of the last meal.

Refractory Disease and Steroid Dependent Disease

Related and requires monitoring with full blood counts weekly for the first month and then subsequently at least four times annually. Thioguanine has been used successfully for patients with allergies to AZA or mercaptopurine, or for patients with high functional thiopurine methyl-transferase activity however, the risk of hepatic complications such as veno-occlusive disease or nodular regenerative hyperplasia has limited the utility of this end product of mercaptopurine metabolism. AZA and 6-MP are also beneficial in perianal disease, including fistulas, and should be continued if tolerated as first line maintenance therapy. There is a separate chapter on AZA use in IBD (see Chapter 69, Monitoring of Azathioprine Metabolite Levels in Inflammatory Bowel Disease).

Management options

It is important that mothers with a previous history of severe allergic reactions are identified antenatally. Wherever possible, the previous anaesthetic record should be obtained and a plan for her care documented. Management of the known allergic case includes a general state of readiness and awareness as well as the obvious avoidance of any known allergens. Latex allergic patients may be identified from the history in most cases by asking about food allergies and skin reactions after exposure, e.g. rubber gloves, condoms, etc. If patients have had a previous severe reaction where the allergen is unknown, pretreatment with H - and H2-antagonists + steroids should be considered, although whether this should be routinely done if the allergen is known and can be avoided is controversial. Routine screening of all women by using skin or blood testing is generally not indicated, since precautions should be taken on the basis of a strong history even if testing produces negative results.

Premenstrual Syndrome Treatment Interventions

Premenstrual Dysphoric Disorder (PMDD), formerly Late Luteal Phase Dysphoric Disorder (LLPDD) Terms that refer to that small percentage of women who have premenstrual syndrome with primarily emotional symptoms severe enough to affect their ability to function at home or in the workplace. Premenstrual Exacerbation Aggravation of such chronic conditions such as asthma, depression, anxiety, eating disorders, substance abuse, headaches, allergies, seizures, or herpes during the premenstrual phase.

Skin Anomalies Pathological Noninfective

Classically this condition is the end-result of intense, chronic pruritus that results from repetitive rubbing or scratching. The skin responds by thickening and the increase in skin markings is referred to as lichenification. This occurs mostly in individuals with a history of allergies, eczema, hay fever or asthma. They have sensitive and easily irritated skin.

Details of medical assessment

Personal history must start with pregnancy, birth, the neonatal period, and subsequent developmental milestones. Then details of immunisations, drug history, and allergies are obtained. Information on the child's performance at nursery or school should include social factors.

Pathophysiology and Diagnosis Inflammation and Extent of Disease

A second issue regarding the histopathology of IBD has emerged over the past few years. In the 1950s, the eosinophil was recognized as a dominant cell in the microscopic picture of IBD. Because it was believed the function of the eosinophil was limited to parasitic infections and allergy, considerable research focused on identifying either of these problems as the etiology of IBD. Parasitic infections were easily dismissed, but it took over a decade to eliminate definitively the allergic etiology of IBD. The eosinophil, which had captured the interest of pathologists studying IBD, subsequently was declared to be a surrogate marker for inflammation. In the 1990s, the homeostatic role of eosinophils began to be understood. An extended pathobiologic role of eosinophil function emerged during the national epidemic of the tryptophan-eosinophilic-myalgia syndrome in which eosinophils caused extensive tissue injury unrelated to parasites or allergies. Tissue resident mast cells release...

Modify Antigenic Structure

Methods to genetically or chemically modify the antigenic structures offoods to reduce their allergic potential are also being developed. For example, it is known that single amino acid substitutions in the IgE binding site of a peanut allergen can lead to the loss of binding to these epitopes. Mutated protein or peptide immunotherapies are promising but unproven strategies to induce desensitisation to food antigens. Traditional Chinese medicine (herbal) used for allergic disorders has been shown to modulate the immune response and to block anaphylaxis in a murine model of peanut allergy suggesting that such treatments may be beneficial in human food allergy. Other experimental therapies are being directed to modifying the intestinal barrier so it is less permeable to food and other types of antigens. Although all these developments hold some promise for food allergy sufferers, none are at a stage of development so as to significantly impact the current way food allergy is treated.

Problems not confined to obstetrics

85 ALLERGIC REACTIONS Most severe reactions on the labour ward are caused by drugs, especially antibiotics, intravenous anaesthetic drugs (particularly suxamethonium) and oxytocin. Some well-recognised cross-reactions exist, e.g. up to 10 of individuals with true penicillin allergy are also allergic to cephalosporins. Allergy to amide local anaesthetic drugs is rare but has been reported, as has allergy to preservatives used in local anaesthetic and other drug preparations. Non-steroidal anti-inflammatory drugs and paracetamol often cause rashes but these are usually mild following brief oral rectal courses, although severe reactions have been reported following intravenous administration. Reactions may also follow administration of gelatine intravenous fluids and blood. Latex allergy has become an increasing problem amongst both medical staff and patients, driven by an increase in the wearing of gloves because of concern about transmission of blood-borne infection and the ubiquitous...

Differential Diagnosis

It is important to consider the differential diagnosis of patients who complain of food-associated GI complaints because the majority will not have food allergy. The major syndrome in which patients complain of adverse reactions to foods is IBS, and other functional bowel presentations. Lactose intolerance is the most common form of food intolerance worldwide and may coexist with other GI conditions as well as food allergy. A complete medical history is often helpful because most patients with a history of food allergy have a family history of atopy, and may have a personal history of other allergic conditions, such as asthma and dermatitis. A history of latex allergy should alert the practitioner to the large number of fruits that can cross-react with latex. Similarly, the oral allergy syndrome occurs in response to inhalant plant allergens, but cross-reactivity with fruit, nut, and certain vegetable antigens is common. Finally, it is well recognized that exercise and medications...

Anaphylaxis Definition

Anaphyalxis is the term used for hypersensitivity reactions that are typically mediated by immunoglobulin E (IgE). Anaphylactoid reactions are similar but do not depend on hypersensitivity. The initial management of both types of reaction is the same and therefore the term anaphyalxis will be used throughout this section (Joint Council of Allergy, Asthma and Immunology 1998)

Treatment Verification

Of imaging would include simulator x-rays, c-arm x-rays, ultrasound or CT scan. For users without x-ray projection imaging, note that CT is acceptable, but for this purpose it need not be a complete scan. A single slice through the balloon center is sufficient. For patients with iodine allergy, instillation of contrast medium into the balloon is contrain-dicated. In such cases, either CT or ultrasound work well. If balloon deflation occurs, a new balloon may be inserted, and the course of treatment completed.

Anaphylactic Reactions

Because it is often difficult to prevent accidental exposure to food antigens, patients with a history of an anaphylac-tic reaction should be instructed to carry an epinephrine-containing syringe for emergency administration. As reactions may be biphasic in nature, patients must be instructed to go to a local emergency facility even after control of the initial symptoms. Individuals who are at increased risk of anaphylaxis include those with a past history of anaphylaxis, those with reactions with respiratory symptoms, those with episodes due the ingestion of peanuts, tree nuts, fish or seafood, and those taking p-blockers or angiotensin converting enzyme inhibitor therapy. Antihistamines, ketotifen, oral cromolyn, leukotriene antagonists and corticosteroids may modify symptoms to food allergens but apart from first generation histamine receptor antagonists, their efficacy in food allergic conditions is largely unproven. Realizing that there are limited studies available from which to...

Placebo Controlled Food Challenge

Because reactions to food antigens by RAST or skin testing are neither specific nor sensitive, a double-blinded placebo-controlled food challenge (DBPCFC), in which food antigens are administered by nasogastric tube or gelatin capsules, should be performed if possible. This technique is considered the gold standard for diagnosing food allergy but is not widely available. The DBPCFC is also less reliable when assessing for delayed reactions to foods and food additives. Clinical history and the results of skin testing help guide the choice of foods to include in the oral challenge. A number of investigators have performed the GI equivalent of skin testing by injecting the GI mucosa with a panel of antigens and observing for a wheal-and-flare response by endoscopy but this form of testing has not been incorporated into routine clinical practice.

Psychological Reactions

In certain individuals, reactions to food may be psychological (Kelsay, 2003). This is a difficult type of ARF to diagnose because the mechanisms giving rise to such reactions are poorly understood. Individuals who are not confirmed to have ARF have higher rates of hypochondria, hysteria, somatization, and anxiety than those with ARF confirmed by food challenge. An individual who experienced a severe ARF may avoid the culprit food for fear of further reactions, and there is also some evidence that hypersensitiv-ity reactions to food may be triggered through central neural mechanisms so that, eventually, just the thought of ingesting the food can trigger allergic symptoms in the absence of antigen. Food allergy itself may lead to psychological distress, and studies of food allergic subjects report an altered quality of life for the individual and their family, with severe manifestations such as anaphylaxis resulting in a post-traumatic stress situation.

Infants and Young Children

In most premature infants, lactase enzyme activity is temporarily low due to the immaturity of the intestine, but a normal lactose-containing formula is well tolerated by most. In infants with symptoms of lactose intolerance, the possibility of milk protein allergy should be excluded.

Standard Computed Tomography

Computed Tomography (CT) scans are usually performed early in the work-up of patients with aortic pathology. Noncontrast CT scans can be completed quickly in order to obtain or confirm a diagnosis and they provide useful information regarding extent and size of the aneurysm, the presence of iliac dilatation, and the existence of hemorrhage or adjacent hematoma. Noncontrast scans are limited by their inability to assess vessel patency but they are useful for patients with renal insufficiency, iodine contrast allergy or cardiac failure. Additionally, noninfused CT is useful for demonstrating significant calcification within the wall of the aorta and its branches. It can also be used to identify associated retroperitoneal, renal, hepatic or bowel pathology.

GI Disorders and ARF Functional Disorders

It is human nature for patients with GI disorders to believe that something in their diet has caused their condition even in the absence of a history of food intolerance. A significant number of GI conditions are associated with ARF but food plays a causal role in only some of these disorders. For patients with GERD, nonulcer dyspepsia, IBS, and other functional conditions, nonspecific physiological reactions to food can provoke symptoms. It is generally advisable to instruct these patients to avoid foods that cause symptoms, but nondietary measures are usually also necessary to manage their complaints. However, food protein intolerance or allergy may play a role in infants with GERD symptoms. There is no generalized role for hypoallergenic diets in IBS, although a few studies report benefit from such diets (reviewed by Spanier et al, 2003) and, in some instances, instituting a rigorous diet is helpful in convincing patients that specific dietary factors are not the sole cause of...

Antimicrobial Treatment of Acute Sinusitis

These agents should be administered to patients where bacterial resistance is likely (i.e., recent antibiotic therapy, winter season, increased resistance in the community), the presence of a moderate-to-severe infection, the presence of co-morbidity (diabetes, chronic renal, hepatic or cardiac pathology), and when penicillin allergy is present. Agents that may be less effective because of growing bacterial resistance may however be considered for patients with antimicrobial allergy. These include the macrolides, trimethoprim-sulfamethoxazole (TMP-SMX), tetracyclines, and clindamycin (74).

Approach To The Child With Anaphylaxis

Anaphylaxis is a potentially life-threatening syndrome which may progress to shock, although in most cases a rash is the only symptom. It is immunologically mediated. The most common causes are allergy to penicillin, to radiographic contrast media, and to certain foods, especially nuts. Table 10.2. Symptoms and signs in allergic reaction

H pylori Eradication Treatment

Based triple regimens are the first line therapies in the United States. These regimens consist of amoxicillin and clarithromycin in addition to a PPI (Table 23-2). FDA-approved treatment durations are 10 or14 days, except for rabeprazole-based triple therapy, which has been approved for 7-day treatment. Another eradication regimen is the quadruple regimen, which includes Pepto Bismol, metronidazole, tetracycline, and a PPI this regimen should be prescribed for 14 days. Per protocol eradication rates are about 85 to 90 for all these eradication regimens. If penicillin allergy exists, metronidazole can be substituted for amoxicillin in the PPI-triple therapy or the quadruple therapy can be used. Selection of initial eradication therapy should include general assessment of prior exposure to the antibiotics in the eradication therapy. If the patient has been exposed to metronidazole, then the quadruple regimen should not be used initially, but rather the PPI-based triple. If the patient...

Approaches To Therapy Based On The Pathophysiology Of Hiv Disease

Considers the use of combinations of agents directed at different viral targets. To evaluate some of the many possible approaches, a large clinical trial program was established by the National Institutes for Allergy and Infectious Diseases. It was and is a major organizational, administrative and scientific challenge and accomplishment to coordinate hundreds of investigators, thousands of patients, and millions of data items in an effort to assess multiple promising therapeutic avenues simultaneously. As of October 28, 1991, 202 trials were pending initiation or had been initiated by the AIDS Clinical Trials Group (National Institute of Allergy and Infectious Diseases, Division of AIDS, 1991). Of the 146 trials that had already been initiated, 19 were preliminary pharmacologic studies, 41 involved treatments of the primary HIV infection, 38 were directed at opportunistic infections, 13 at AIDS-related cancers, 3 at neurologic complications, 20 at pediatric HIV disease, and 12 at...

Engaged in this function

Early in 1957, Burnet received a preprint of a review entitled Allergy and Immunology by David Talmage (1957), then at the University of Chicago. Although much of the paper was devoted to issues specific to allergy, the paper summarized existing immunological theories and encapsulated a new model of antibody production. Despite couching his new model in tentative phrasing (As a working hypothesis it is tempting to consider. . . ), his incisive dealing with the problems associated with previous models and the explanatory power of the model proposed betrayed a prodigious intellect and a great depth of thought on the subject. He borrowed from Burnet and Jerne, as well as from the model proposed by Ehrlich (1900) in which an antigen bound to specific cell-surface receptors and thereby triggered the cell to secrete soluble copies of antibodies with the same specificity as the particular receptor ligated (see Fig. 3.1). Talmage produced a hybrid model in which he proposed (1) that an...

Patients And Methods

Forty-one BD patients, 25 male and 16 female, aged from 19-46 years, registered at the BD Clinic at Saddam Medical City and fulfilling the International Study Group Criteria (ISGC) for the diagnosis of BD7 and 37 healthy individuals, 19 males and 18 females, with an age ranging from 2538 years, participated in the study. Control individuals had no history of serious illness, were normal on physical examinations and had no history of sulphonamide allergy or G6PD deficiency. Smokers, drinkers and those taking medications in the last week were excluded. All subjects gave their informed consent. The study was approved by the ethics committee.

Th1 versus Th2 Cytokines in Humoral Autoimmunity

During immune responses, all helper CD4+ T (Th) cells produce interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), but differences in environmental stimulation skews them broadly towards two subtypes bearing distinct patterns of cytokine production (1) Th1 cells, which produce predominantly IL-2, interferon-y (IFN-y), lymphotoxin (LT), and tumor necrosis factor-a (TNF-a) and (2) Th2 cells, which produce IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 75-77 . This dichotomy has become less clear as recent studies have further detailed the increasingly complex environments of natural immune responses 78, 79 , but nevertheless it has remained of great utility because Th1 cytokines have consistently been associated with cellular immune functions, such as delayed-type hypersensitivity and macrophage activation, while Th2 cy-tokines have been associated with B cell-dependent antibody responses, such as allergy 76, 80 . As such, humoral autoimmune diseases were...

Genetically complex disorders

In atopic eczema, matters are equally complicated. Environmental factors may well be responsible for the recent rise in its prevalence as the gene pool within the population is not likely to have changed greatly, but a genetic component is obvious too, even though affected children can be born to clinically normal parents. Within each family, atopic disorders tend to run true to type, so that, in some, most affected members will have eczema, in others, respiratory allergy predominates. The inheritance of atopic eczema probably involves genes that predispose to the state of atopy, and others that determine whether it is asthma, eczema, or hay fever that develops. One plausible gene for the inheritance of atopy encodes for the p subunit of the high affinity IgE receptor, and lies on chromosome 11q13. However several groups have failed to confirm earlier reports of this linkage, and a gene linked to atopic eczema has recently been found on chromosome 3q21.

Characteristics of staff authorised to take responsibility for the supply or administration of medicines under Patient

Clinical condition - The PGD is applicable to any patient (male or female) who has been diagnosed with genital candidiasis. Genital candidiasis is a fungal infection and is commonly caused by the species Candida albicans. In women the sites of infection may include the vulva, vagina and the urethra, and in men the most common sites include the glans, prepuce and urethra. Signs and symptoms are variable. Women may complain of a thick white vaginal discharge, pruritus, soreness, erythema, dysuria and dyspareunia. Fissuring may be apparent on the vulva. Men may present with a visible rash on the glans and they may also complain of pruritus and dysuria. Diagnosis is confirmed either clinically, microscopically (by wet and dry slide) or by culture media. Inclusion criteria - symptomatic patients who have had Candida diagnosed clinically and or microscopically, and symptomatic patients who have had Candida diagnosed on culture. Exclusion criteria - this includes female patients who have...

Therapy of Extensive Disease

Sulfasalazine may be started at 1 g daily with an increase in the dose by 1 g each day up to the target dose of 3 to 4 g d, if tolerated. The complete blood count should be checked after a week to look for toxicity, especially leukopenia. However, there are several drawbacks to using sulfasalazine instead of one of the newer 5-ASA preparations. Sulfasalazine should not be used in patients with a history of sulfa allergy. Besides allergic reactions, some patients develop headaches, nausea, anorexia, and other dose-related adverse effects. Sulfasalazine may cause reversible male infertility, which does not occur with the other oral 5-ASA medications.

Gonadotropin Ovulation Induction

Exogenous gonadotropins have traditionally been used in PCOS patients who are resistant to ovulation induction with clomiphene and more recently those not responding to the addition of metformin or laparoscopic ovarian drilling. Gonadotropin preparations derived from hMG, a mixture that contains FSH, LH, and large quantities of urinary proteins, have been in use since the early 1960s (97). Other gonadotropin preparations in use today include purified urinary FSH (uFSH) and recombinant FSH (rFSH). Highly purified uFSH contains a reduced amount of LH and very small amounts of urinary proteins. The lack of urinary proteins in this preparation reduces adverse reactions such as local allergy or hypersensitivity (98). Preparations of rFSH were recently developed with a complete absence of LH and co-purified proteins, giving high specific bioactivity. These preparations share similar pharmacokinetic characteristics with purified uFSH (99). Whereas hMG is administered intramuscularly, uFSH...

Immediate hypersensitivity

This type of reaction is caused by reagin antibodies, which consist mainly of lgE, that react with allergens such as housedust mite, animal dander, or grass pollens. These reactions may occur in both the skin or the lung to produce asthma. Allergic reactions to insect stings can cause severe systemic effects anaphylaxis, which literally means without protection. Food proteins can also cause an immediate type of hypersensitivity reaction. The IgE molecule is attached to specific receptors on the surface of mast cells and when activated by linkage to specific allergen inflammatory mediators are released. This is an acute process, hence the name immediate hypersensitivity.

Benzoic acid derivatives

PGD2 is the major cyclooxygenase product formed and secreted by activated mast cells during allergic reactions. However, the lack of suitable antagonists for its receptors, CRTH2 and DP, has limited progress toward elucidating the role that PGD2 plays in allergic diseases. The recent discovery of potent and selective antagonists for CRTH2 and DP receptors, coupled with the genetic analysis of DP and CRTH2 function using KO mice, as well as the discovery of selective agonists

Primary Low Grade BCell Lymphoma of the MALT Type and Immune Deviation

The occurrence of mucosa-associated lymphoid tissue (MALT) is not a ubiquitous finding in the nasolacrimal ducts (although it is a feature commonly found in symptomatically normal nasolacrimal ducts) 19 and is acquired in response to antigenic stimulation. Loss of tear-duct-associated lymphoid tissue (TALT) seems to be associated with the scarring of symptomatic dacryostenosis, suggesting that the presence per se of TALT does not lead to scarring 21 . Whether special types of bacteria, viruses, allergic reactions, or other factors, such as some type of immune deviation (see below), are responsible for the development of TALT in humans is not clear at present however, the occurrence of TALT may favor the rise of primary low-grade B-cell lymphoma of the MALT

Etiology and Risk Factors

The etiology of PMS and the factors that place a woman at risk for developing PMS remain uncertain. Etiologic hypotheses that have been proposed include abnormalities in hormonal secretory patterns (ovarian steroids, melatonin, androgens, prolactin, mineralo-corticoids, thyroxin, insulin), neurotransmitter levels (biogenic amines such as epinephrine and norepineph-rine, endogenous opioids), circadian rhythms (temperature, sleep), prostaglandins, vitamin B6 levels, nutrition, allergic reactions, stress, and other psychological factors. Although investigators may advocate vehemently for one or more of these possibilities, no single, fully explanatory mechanism has been isolated as yet. Furthermore, there are physiological and behavioral correlates of menstrual cycle rhythms such as increases in appetite premenstrually and abdominal discomfort during menstruation that are present in women without PMS. These findings have led to the belief that the etiology of PMS resides in the...

Effective Therapeutic Agents

There is no question but that 6-MP AZA is an effective agent both in closing and maintaining closure of fistulas. These agents are quite safe long term with no definite evidence of the development of neoplasia or superinfections. Toxicity is mainly limited to allergic reactions, including rash, fever, pancreatitis, and to those patients who are thio-purine methyl transferase deficient. In this group lower doses must be used to prevent the development of leukopenia.

Identifying The Vascular Lesion

Cta Absent Right Pcom

Despite its advantages, diagnostic catheter angiography is now almost never performed for evaluation of acute stroke in institutions that have access to modern CT and MR scanners. There are several reasons for this. Catheter angiography requires the presence of highly trained angiographers, technologists, and sometimes anesthesiologists, some of whom may not be immediately available at all times of the day. It is a relatively time-consuming technique, and it may unacceptably delay the initiation of therapy in the acute stroke patient. The iodinated contrast used for catheter angiography can result in nephrotoxicity and allergic reactions, which are discussed in the next section. Also, catheter angiography is a highly invasive and somewhat risky procedure. Complications may occur if atherosclerotic plaques are dislodged from the aorta during catheter passage or if small thrombi There are two widely used noncontrast-based MRA techniques time-of-flight (TOF) MRA and phase contrast (PC)...

Cladosporium Herbarum Nasal Problems Mexico

Cladosporium, Alternaria, Penicillium, Aspergillus, and Mucor were reported to be the commonest allergenic fungi (Furuuchi and Baba, 1986 Malling et al., 1985). Cladosporium is believed to be the most common one causing mold allergy (Malling et al., 1985). However, the most prevalent airborne fungi are not necessarily the most potent allergens, at least as determined by prick testing (Terracina and Rogers, 1982). Spores of Alternaria alternata and those of the closely related genera Stemphylium and Ulocladium are considered to be the most important mold allergens in the United States (Hoffman, 1984 O'Hollaren et al., 1991 Reed, 1985). Penicillium exposure was a risk factor for asthma, while Aspergillus exposure was a risk factor for atopy (a genetic trait of increased allergen sensitivity) (Garrett et al., 1998). Curvularia lunata was found to be a cause of allergic bronchopulmonary disease (Halwig et al., 1985). Epicoccum nigrum was reported to be able to colonize nasal sinuses and...

IgE Receptor Crosslinking And Activation Of Apcs

As previously mentioned, DCs play a critical role in the regulation of TH cell responses via the secretion of various soluble factors and the expression of membrane associated co-stimulatory molecules. Since interaction of allergen with surface bound IgE-FceRI complex results in the release of inflammatory mediators and upregulates the production of various cytokines, it is conceivable to assume that FceRI could be a key molecule which connects IgE-mediated allergic reaction and the preferential induction of TH2 type T-cell activation, as observed in AD patients (17).

Sheila E Crowe Md Frcpc

Adverse reactions to food (ARF) are common, with up to 50 of some populations reporting ARF (Table 57-1). The majority of ARF are nonimmunologic in origin, but true food allergies are thought to affect up to 6 to 8 of children under the age of 10 years and 1 to 2 of the adult population (Sampson, 2003), a frequency which should result in most medical practitioners seeing cases of food allergy on a regular basis. The major difficulty in managing patients with food allergy lies in making a diagnosis of food allergy, particularly when the symptoms are primarily gastrointestinal (GI). Over 50 years ago Ingelfinger and colleagues (1949) wrote gastrointestinal allergy is a diagnosis frequently entertained, occasionally evaluated, and rarely established and even today this is an apt description of the problem confronting clinicians considering a diagnosis of GI food allergy. However, substantial developments have been made in our understanding of the basic biology of food allergy with...

Eosinophilic Gastroenteritis

Food allergy is thought to play a role in some cases of eosinophilic gastroenteritis, a relatively rare condition characterized by eosinophilic infiltration of the gut and, often, peripheral eosinophilia. Approximately half the patients with eosinophilic gastroenteritis have atopic features, including food allergy. Strategies to identify and eliminate food antigens should be followed as in other food allergic conditions, but often other measures, particularly corti-costeroids, are necessary to manage patients with eosinophilic gastroenteritis. Even after thorough evaluation for parasites, an empiric course of antihelminthic therapy may be given before embarking on a course of corticosteroids. Allergic eosinophilic esophagitis presents in infancy through adolescence and manifests with symptoms of gastroesophageal reflux that are often refractory

Intraoperative precautions

Dakin MJ,Yentis SM 1998 Latex allergy a strategy for management.Anaesthesia 53 774-81. Fisher MMCD 1997 Latex allergy during anaesthesia cautionary tales.Anaesthesia & Intensive Care 25 302-3. Kam PCA, Lee MSM,Thompson JF 1997 Latex allergy an emerging clinical and occupational problem.Anaesthesia 52 570-5. Moneret-Vautrin DA, Laxenaire MC 1991 Routine testing for latex allergy in patients with spina bifida is not recommended. Anesthesiology 74 391-2. Patterson LJ, Milne B 1999 Latex anaphylaxis causing heart block role of ranitidine. Canadian Journal of Anaesthesia 46 776-8. Rae SM, Milne MK,Wildsmith JAW 1997

Anaphylactoid or Pseudoallergic

Anaphylactoid or pseudoallergic reactions to food result from foods that mimic the effects of mast cell degranulation but do not involve IgE antibodies. Strawberries and shellfish may cause this type of ARF. Certain food ingredients, including additives such as salicylates, benzoates, and tartrazine, induce pseudoallergic reactions. As with true food allergy, patients exhibiting such reactions should be instructed to avoid the offending food substance if identifiable. Pharmacological reactions to food or food additives represent a relatively common type of ARF, although most of these reactions cause symptoms outside of the GI tract. Histamine found in certain cheeses or in scrombroid fish, such as tuna, can cause headaches and diffuse erythema of the skin. Certain individuals develop migraine headaches to various foodstuffs, including those rich in amines. Sulfites, tartrazine and monosodium glutamate (MSG) have all been associated with asthma, and MSG can cause a characteristic...

Supplemental Reading

Carroccio A, Iacono G, Montalto G, et al. Pancreatic enzyme therapy in childhood celiac disease. A double-blind prospective randomized study. Dig Dis Sci 1995 40 2555-60. de Francischi ML, Salgado JM, da Costa CP. Immunological analysis of serum for buckwheat fed celiac patients. Plant Foods Hum Nutr 1994 46 207-11. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue trans-glutaminase as the autoantigen of celiac disease. Nat Med 1997 3 797-801. Ellis HJ, Doyle AP, Day P, et al. Demonstration of the presence of coeliac-activating gliadin-like epitopes in malted barley. Int Arch Allergy Immunol 1994 104 308-10. Ellis HJ, Doyle AP, Wieser H, et al. Measurement of gluten using a monoclonal antibody to a sequenced peptide of alpha-gliadin from the coeliac-activating domain I. J Biochem Biophys Methods 1994 28 77-82.

Antimicrobial Therapy of Chronic Sinusitis

Risk factors prompting a need for more effective antimicrobials3 Bacterial resistance is likely Antibiotic use in the past month, or close contact with a treated individual(s) Resistance common in community Failure of previous antimicrobial therapy Infection in spite of prophylactic treatment Child in daycare facility Winter season Smoker or smoker in family Presence of moderate-to-severe infection Presentation with protracted (more than 30 days) or moderate-to-severe symptoms Complicated ethmoidal sinusitis Frontal or sphenoidal sinusitis Patient history of recurrent acute sinusitis Presence of co-morbidity and extremes of life Co-morbidity (i.e., chronic cardiac, hepatic or renal disease, diabetes) Immunocompromised patient Younger than two years of age or older than 55 years Allergy to penicillin Allergy to penicillin or amoxicillin

Efficacy and Safety of CAM

Severe hepatotoxicity from some herbal products. However, in general, there are no major safety concerns with the common forms of therapy (herbs and nutritional supplements) used by GI patients. Potential risks include allergic reactions, contamination or mislabeling of herbal products, nutritional deficiencies resulting from restrictive diets, and neck and spine injury resulting from spinal manipulation. However, physicians and patients should be aware that some therapies are associated with the risk of serious side effects due to the therapy's chemical constituents (eg, hepatic veno-occlusive disease from herbs such as comfrey that contain pyrrolizidine alkaloids), contamination with heavy metals (reported with some medicines prepared in Asia), and the potential risk for toxicity to the fetus.

The itching skin pruritus

Eczema is associated with itching due to the accumulation of fluid between the epidermal cells that are thought to produce stretching of the nerve fibres. As a result of persistent scratching there is often lichenification which conceals the original underlying areas with eczema. Exposure to irritants and persistent allergic reactions can produce intense itching and should always be considered. Allergic reactions due to external agents often cause intense itching. Systemic allergic reactions such as a fixed drug eruption, erythema multiforme, and vasculitis are less likely to cause pruritus. Patch testing for allergies Topical local anaesthetics may give relief but intolerance develops and they can cause allergic reactions. Sedative antihistamines at night may be helpful. In liver failure cholestyramine powder may help to relieve the intense pruritus, as this is thought to be due to bile salts in the skin. Avoid harsh toilet paper, especially if coloured, because cheap dyes irritate...

Eczematoid Dermatitis


Eczema of the meatus and surrounding structures may affect any age group. It may be familial atopic dermatitis, acquired-irritant, or allergic eczema. The lesions usually start as small blisters, which itch intensely and are scratched away, leaving skin that becomes lichenified with exaggerated striations and scales. Weeping of sticky clear fluid is often present. Allergy to topical irritants, such as fabrics, soap, hair coloring, or hair spray, as well as other environmental allergens, may be causative. Neomycin allergy from eardrops can cause an acute eczema (Fig. 4.5), aggravating a condition you may be already treating In addition, food allergy has been implicated eggs, milk, cheese, chocolate, and nuts head the list.

Ear Nose and Throat Disease

GERD may be associated with a number of ENT syndromes, including recurrent hoarseness, throat clearing, sore throat, and globus, and signs, such as laryngitis, vocal cord granulomas, ulcers, leukoplakia, sinusitis, and even laryngeal cancer. These patients are usually diagnosed by our ENT colleagues based upon symptoms and signs of inflammation involving the posterior third of the vocal cords and interarytenoid areas, which are both in close proximity to the upper esophageal sphincter. However, the specificity of these findings has recently been questioned our study in 100 healthy volunteers without ENT complaints found signs associated with reflux laryngitis in 86 of these subjects (Hicks et al, 2002). In these individuals, other causes could usually be found, including smoking, alcohol, excessive voice use, allergies, or asthma.

Thoracoabdominal Aortic Aneurysm Repair

Interrupted Rectal Temperature

Define size, location and extent as well as intraluminal thrombus or calcification (Fig. 21.5). CT scan can also uncover other pathology in the chest and abdomen such as lung or kidney disease. In patient follow-up, the CT scan is indispensable for documenting aneurysm growth rate. Renal insufficiency or allergies to contrast agents may contraindicate CT scan. MRI is as good as CT scan in delineating the presence of TAA, its characteristics and etiology (Fig. 21.6). It is noninvasive and does not require contrast medium. Drawbacks are cost and the time required to run the test. A pacemaker or patient claustrophobia are contraindications. TEE reliably surveys aortic valve disease, aortic dilatation, ascending aortic aneurysm, dissection, thrombi, atherosclerotic disease and mitral valve disease. It provides an assessment of cardiac structure and function and is highly sensitive in aortic pathology diagnosis. TEE nonetheless is a poor identifier of aneurysm below the diaphragm and in...

Biophysiological Factors

Presenting problems may be related to neurological or biochemical factors. Such factors may place boundaries on how much change is possible. Malnutrition, hypoglycemia, and allergic reactions have been associated with hyperactivity, learning disabilities, and mental retardation. Biochemical abnormalities are found in some children with serious behavior disturbances such as those labeled autistic. However, this only establishes that abnormalities in biochemistry are present, not that they cause a certain disorder (e.g., cause certain behaviors). Biochemical changes may be a result of stress related to social conditions such as limited opportunities due to discrimination. Drugs, whether prescribed or not, may influence how clients appear and behave. Certain kinds of illness are associated with particular kinds of psychological changes.

Problems associated with insulin injections

Insulin Injection Site Complications

Red itchy marks at injection sites after starting insulin are also rare, and if they do occur usually disappear spontaneously. If they are very troublesome, adding hydrocortisone to the insulin bottle so that each dose contains about 1 mg eliminates the problem. Insulin allergy causing urticaria still occurs from time to time though it is certainly a very infrequent event investigation by skin testing and desensitisation may be needed. Abscesses at injection sites are also remarkably rare.

Implementation Of An Acute Stroke Team And Acute Stroke Protocols

The overwhelming prerogative, in thrombolysis for acute ischemic stroke, is the need for rapid, yet complete, evaluation of potential therapeutic candidates within the 3-hour treatment window. Time is the acute stroke clinician's worst enemy.33 The acute stroke protocol should begin at the first of point of contact with the healthcare system the call to an ambulance dispatcher. Stroke symptoms should be recognized and given high priority for dispatch. Emergency medical technicians (EMTs) should be trained to identify potential thrombolysis candidates in the field by recognizing signs of stroke,73,74 and several simple scales have been created for this purpose.75-78 Prenotification by the EMTs, before hospital arrival, allows time for notification of the acute stroke team and preparation of the CT scanner before patient arrival, and has been associated with fewer in-hospital delays in treatment.79,80 The initial evaluation, after arrival in the emergency department, should include a...

Treatment of Olfactory Disorders

Other treatments In addition to the use of steroids there are other therapeutic approaches to restoration of olfactory loss. They include the use of anti-leukotrienes 243 , saline lavages 244 , or approaches which have received less vigorous scientific investigation, e.g., dietary changes 245 , acupuncture 246 , anti-allergy immunotherapy 247 and herbal treatments.

Management of Internal and Mixed Hemorrhoids Nonsurgical Treatment

Injection sclerotherapy has been used for hemorrhoidal disease treatment for over 100 years. Indicated to treat bleeding first, second, or early third degree internal hemorrhoids, a small amount of a sclerosing agent is injected above the dentate line. Five percent phenol in vegetable oil has been traditionally used, but other agents such as quinine, urea hydrochloride, and sodium morrhuate, are available. It is a straightforward, quick, painless, and inexpensive method, with success reported in up to 75 of patients. Although complications of pelvic sepsis and perianal necrosis have been reported, sloughing of the overlying mucosa, local infections, and allergic reactions to the injected material are more commonly described side effects.

Elimination Diets and Diet Supplements

Cluded that most research shows no credible evidence for the effectiveness of such diets in treating ADHD. He did note that such diets may be helpful for a small subset of children who have specific food allergies, but there is no evidence that children with ADHD have any greater incidence of such food allergies than children in the general population.

Retraction of the Tympanic Membrane

The cause of the obstruction, as discussed in the section on the eusta-chian tube, should be addressed. One should look for infection, allergy, or obstructing lesions in the nasopharynx. Treatments addressing the eusta-chian tube have often included antihistamines, decongestants, and nasal steroids. Unfortunately, there is not much objective evidence in the literature that these are effective, but they make empirical sense and help associated nasal symptoms. Of course, bacterial sinonasal infection can be treated with antibiotics.

Organization Of This Book

Internal Medicine (including infectious disease, immunology, and allergy diseases of the respiratory, cardiovascular, hematopoi-etic, gastrointestinal, renal, musculoskeletal, nervous, and integumentary systems nutritional, metabolic, endocrine, oncologic, and fluid and electrolyte disorders clinical pharmacology legal medicine)

Order Set Schema OS Schema

- Patient Data - contains patient-specific data, such as past clinical history (e.g., medications, laboratory test results, allergies, previous diagnoses, family history), and current diagnosis. - Knowledge Rules - provides real-time decision support for medication errors, dosage error, and adverse drug interactions, known patient allergies, calculate dosages based on the patient, and standardized care. It also provides links to alternative, complementary supporting knowledge.


Identification and isolation of specific food antigens has facilitated identification and molecular characterization of B- and T-cell epitopes of these allergens in peanut, egg and milk. The B-cell epitopes of Ara h 1, Ara h 2, and Ara h 3 have been mapped and identified (11, 12,13) however, the response of T cells to these allergen has not been determined. Ten IgE-binding epitopes were identified for Ara h 2 and epitopes 3, 6, and 7 where recognized by all of the patient sera tested (13). Single amino acid changes in the immunodominant epitopes of Ara h 2 caused loss of IgE binding (7). Here, 5 immunodominant T-cell epitopes have been identified for Ara h 2 only one of which overlaps with a major B-cell epitope. No significant amino acid homology was seen among the epitopes identified. Non-allergenic individuals seemed to recognize some of the same epitopes as allergic individuals. Although both T-cell lines from atopic and non-atopic individuals were found to have a Th2-like...

Patch Testing

Diagnostic tests for non-IgE-mediated food allergies include food allergy patch testing, T-cell cytokine assays, and measurements of markers of eosinophil activation. Conventional patch testing is used to diagnose contact hypersensitivity reactions involving T cells and has been applied to the evaluation of food allergy in the setting of atopic dermatitis and allergic eosinophilic esophagitis, primarily to cow's milk proteins (De Boissieu et al, 2003). Other tests may be useful in specific conditions, such as 24hour pH monitoring in eosinophilic esophagitis. Occult parasitic infections should be excluded in order to diagnose idiopathic or allergic eosinophilic syndromes and, occasionally, a course of empiric antihelminthic therapy may be indicated. Histological analysis is important in many presentations of food allergy including eosinophilic esophagitis, food protein-induced enterocolitis and proc-tocolitis, and celiac disease.

Dietary Restrictions

Dietary restrictions for food allergy associated with ana-phylaxis and celiac disease should be maintained on a long term basis, whereas such measures can be lessened in other types of food allergy that resolve with time, particularly those presenting in early childhood. At one time it was thought that unlike other food allergies, peanut allergy was not outgrown. However, there are recent studies that indicate that there may be as high as a 50 chance of outgrowing a peanut allergy. As noted above, skin testing cannot be used to predict loss of clinical reactivity because skin tests may remain positive in a child who no longer has clinical manifestations of food allergy. Instead a decline in specific IgE levels followed by a negative oral challenge provides a better index of clinical loss of reactivity to a specific food antigen. To date, there is no definite evidence that oral desensi-tization, injection immunotherapy, or similar techniques used for allergies to inhalant allergens,...


Erythema is macular redness of the skin due to congestion in the capillaries. It occurs as part of immunological reactions in the skin as in drug allergies and specific patterns of viral infections, such as measles. There are other types that show a specific pattern but are associated with a wide range of underlying conditions, such as erythema multiforme.

Costbenefit Issues

The most important risks inherent to iodinated contrast administration are allergic reaction and injury to the kidneys. Patients with a history of prior allergic reaction to iodinated contrast material, asthma or other allergies are at increased risk. The decision to perform contrast enhanced CT is dependent on the severity of the prior reaction and feasibility of appropriate antiallergic premedication. Patients with elevated creatinine, diabetes mellitus, renal transplant, multiple myeloma, nephrotoxic medication, and severe chronic heart failure are at risk for renal failure after contrast injection. Hydration, reduced dose of contrast material, and use of isoosmolar contrast agents are options to reduce nephrotoxicity in this vulnerable patient population. However, alternative methods, particularly MR imaging, should be considered if available and no contraindications exist.

Acyclic dimer

Hypotensive effects are possible when DMPS is given parenterally (Klimova, 1958). The intravenous use of this chelating agent should be reserved for the treatment of acute poisonings since oral DMPS preparations are available for all other uses. If the patient has a history of allergies to penicillin, sulfonamides and or other sulfur-containing drugs, neither DMPS nor DMSA should be used.

Initial Assessment

A detailed clinical history, past medical and surgical history, medications, allergies, laboratory work-up, physical examination, and NIHSS should be obtained as quickly as possible for assessment of inclusion and exclusion criteria for IAT. Table 4.1 lists the criteria for catheter-based reperfusion therapy currently in place at the Massachusetts General Hospital (Table 4.1 see also for updated criteria).

Adverse reactions

The majority of patients tolerate penicillins well, the most common adverse effects being mild and gastrointestinal in nature. However, penicillins are also well documented as causing hypersensitivity reactions in some patients, some of which prove to be fatal. If a patient is allergic to one penicillin, then they will also be allergic to the entire class. Additionally, 10 per cent of penicillin-allergic patients will also exhibit an allergy to cephalosporin antibiotics. A skin rash is the most common presenting sign of allergy.

Order Group Category

OrderGroup category in Fig. 19 groups orders in an OS by type. Orders are referred to by OrderID - a unique identifier for each order. An order type can be any of following (list not exhaustive) Admission, Monitoring, Nursing, Medications Tubes-Drains, Lines-IVs, Image Rx-Dx, Laboratory Results, Allergy, Consults, Diet, Wound Care, Patient Activity, Discharge List,

Adverse effects

Most side-effects are gastrointestinal. Erythromycin in particular can cause nausea and vomiting in some patients. Clarithromycin and azithromycin are tolerated better, and are good alternatives in patients who are intolerant of erythromycin. Some patients are allergic to macrolides, and a hypersensitivity to one macrolide confers cross-class allergy. Erythromycin has also been known to cause reversible hearing loss. Erythromycin is safe to use in pregnancy and lactation. Azithromycin is not licensed in the UK for use in pregnancy however, some GUM centres use it in pregnancy following a detailed discussion with the mother-to-be.

Immune reactions

Allergic reactions to drugs such as penicillin can occur. In this case the penicillin molecule attaches to serum protein. This compound acts as an antigen and may form a complex with IgG antibody. It is this complex which attaches to blood vessel walls to produce an inflammatory reaction. This presents as a rash developing a few days to two weeks after treatment on the skin, but if it occurs in the kidneys the resulting tissue damage can have serious consequences. This is an example of Type III allergy with antigen-antibody complexes being deposited in the small blood vessels. Sometimes a much more acute anaphylactic reaction develops A fixed drug eruption is characterised by a localised patch of erythema that flares up whenever the drug is taken. Erythema multiforme can occur in drug reactions.


Dose 0-4 ml kg per rectum (0-3 ml kg under 6 months of age), made up as a 50 50 solution in olive oil or physiological saline. Arachis oil should be avoided as children with peanut allergy may react to it. Paraldehyde can cause rectal irritation, but intramuscular paraldehyde causes severe pain and may lead to sterile abscess formation. Paraldehyde causes little respiratory depression. It should not be used in liver disease.


Camara A, Becherel PA, Bussel A, Lagrange S, Chosidow O, Joly P, Piette JC, Frances C (1999) Resistant acquired bullous epidermolysis with severe ocular involvement the success of extracorporeal photochemotherapy. Annal Dermatol Venereol 126 612-615 Chan LS, Fine JD, Briggaman RA, Woodley DT, Hammerberg C, Drugge RJ, Cooper KD (1993) Identification and partial characterization of a novel 105-kDalton lower lamina lucida autoantigen associated with a novel immune-mediated subepidermal blistering disease. J Invest Dermatol 101 262-267 Chan LS, Woodley DT (1996) Pemphigoid Bullous and cicatricial. In Current Therapy in Allergy, Immunology and Rhematology, 5th ed, edited by LM Lichtenstein, AS Fauci Mosby, St Louis, p 93

Toxic Effects

The literature contains many references to Mugwort pollen due to its allergenic effects. For example, Nilsen and co-workers have published a series of papers which identified and characterized allergens from the pollen using a variety of immunological techniques (Nilsen, 1990a,1991a) and have purified allergen Ag7 by con-canavalin A affinity chromatography (Nilsen, 1990b). They have also reported the structural analysis of the glycoprotein allergen in Mugwort pollen (Nilsen et al., 1991b).

Blood Tests

A radioallergosorbent test (RAST) can be used as an alternative to skin testing in very young children, those with severe atopic dermatitis, those who cannot discontinue antihistamines, and those reporting anaphylactic reactions to foods or food additives. The limitations of RAST are the expense, lower sensitivity, and relatively limited number of antigens that can be tested when compared with skin testing. A modification of the traditional RAST test, the CAP System FEIA (Pharmacia), is reported to be more sensitive than a standard RAST. Levels of food-specific IgE above which a patient has a > 95 likelihood of experiencing an allergic reaction after the ingestion of specific food have been established (Sampson, 2002). An oral food challenge is recommended at lower levels of food-specific IgE because the clinical significance of such levels cannot be predicted.


The side effect profile of infliximab has been well described through previous adult clinical trials. In children, infusion reactions may be present in as many as 10 of infusions (Crandall and Mackner, 2003). Acute infusion reactions typically involve symptoms such as flushing, headaches, tachycardia, chest tightness, and overall anxiety, and they usually resolve by stopping the infusion. Once symptoms resolve, most patients will tolerate a slower rate of infusion. Because of the frequency of this type of reaction, we routinely administer acetaminophen 15 mg kg by mouth (650 mg maximum) and diphenhydramine 1 mg kg by mouth (50 mg maximum) as premedication before the infusion. More severe reactions during an infusion are rare but do happen, and typically involve oxygen desaturation and hypotension. These require more aggressive resuscitative efforts, including administration of supplemental oxygen, epinephrine, and hydrocortisone. The delayed hypersen-sitivity reactions typically...


Prophylactic intraoperative antibiotic therapy has been shown to reduce the incidence of sepsis following Caesarean section and should be routine. Usually this is given by the anaesthetist administration is often delayed until after delivery to avoid drugs passing into the fetus. Also, should an allergic reaction occur, the baby will already have been delivered.

Adverse Events

Major side effects attributable to sulfasalazine include allergic skin reactions, hemolysis, neutropenia, and mild allergic reactions with rash and fever. During sulfasalazine therapy, the patient's hematologic status should be monitored. Sulfasalazine may interfere with dietary folate absorption, and routine oral folate replacement with 1 mg d is suggested unless red blood cell folate levels are monitored. Fortunately, serious idiosyncratic reactions (eg, hepatitis, pancreatitis, alveolitis, and serum sickness) are very uncommon.

Antiplatelet Agents

Unless contraindicated, aspirin is the most commonly prescribed medication to prevent adverse cardiovascular events. When contraindicated, other antiplatelet agents are available for patients with high cardiovascular risks. Most common contraindications include allergic reactions to aspirin, bleeding, anticoagulant therapies, gastrointestinal bleeding, and clinically active hepatic disease.

Industrial Hygiene

Finally, access to sufficient IH skills is needed by the bulk drug process development function. Many IH issues are not in the scope of the toxicology function of drug development and require an additional set of skills, overlapping with operational safety and occupational health regulations as well. In one instance, a seemingly adequate containment of fumes and ventilation in an area where phosphorus pentachloride was handled could not prevent a very mild baseline irritation of respiratory mucosa of workers such that, upon their subsequent handling of a penicillin derivative in the next production campaign, severe allergic reactions developed. Nevertheless, the practitioner of bulk drug process development should be more than just aware of the IH issues and is hereby referred to some suitable introductory material (24, pp. 22-81).



The first step in dacryolith formation could be a change in tear-fluid rheology with the formation of a yet uncharacterized amorphous material (hypotheti-cally the amorphous material might consist of degraded substances of the ocular tear-film components and develops based on water extraction by the epithelium of the nasolacrimal ducts from causes as yet unknown). In most cases, the material formed initiates an epithelial reaction with increased production of secretory components (TFF peptides, distinct mu-cins) in the nasolacrimal passage, based perhaps on mechanical irritation or bacterial colonization with immigration of granulocytes and production of antimicrobial substances. Fungal colonization also seems to occur in some cases. In this scenario, differences in the composition of dacryoliths with regard to mucins and defense cells may be explained by colonization with distinct bacteria however, it is not clear yet whether dacryolith formation occurs as a reaction to previous...

Mosaic Trisomy

Mosaic Trisomy

Another example of sucking blisters in an infant at 6 days of age. Note that the mucous membrane portion of the lip has a superficial furrowed appearance. With time, the outer layer dries with lifting and shedding of the cornified epithelium and new blisters may develop for a few weeks. They occur most commonly in breast-fed infants or babies who feed vigorously. Pathologically, this can also occur from overheated formula, or as an allergic reaction to the components of the nipple or the formula.