Metformin can be given together with insulin to overweight Type 2 diabetic patients: this can to a small extent limit the inevitable weight gain following introduction of insulin. A combination of sulphonylureas with insulin gives little benefit and has the added disadvantage that patients must continue with both modes of treatment.
Insulin regimens suitable for Type 2 diabetic patients are described in chapter 5.
The figure showing the cross sectional and 10-year cohort data for HbÄ1c in patients receiving intensive or conventional treatment is adapted from UKPDS Lancet 1998;352:837-53 with permission from Elsevier Science. The histogram showing increased patient compliance is adapted from Paes AH, Bakker AS, Soe Agnie CJ. Impact of dosage frequency upon patient compliance. Diabetes Care 1997;20:1512-17.
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