Lymphoma occurs more often in HIV positive patients, particularly in those with advanced HIV disease. Most lymphomas are B cell in origin and are of high grade. Intrathoracic disease most frequently occurs in the context of disseminated disease. Symptoms are non-specific. The chest radiograph may show mediastinal lymphadenopathy, pleural lesions or focal parenchymal abnormalities. The prognosis is poor and there is a high relapse rate after treatment. Median survival is <1 year, reflecting the advanced stage of HIV disease.

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