Fig. 5. Anti-inflammatory activity of ^-941. Dose-dependent inhibition of cutaneous irritation in humans by ^-941.

well as psoriasic patients have been obtained. Despite the small number of patients per dose, these data showed a significant trend in favor of a dose/response effect on the patients' clinical benefit, body weight loss, and analgesic consumption (p < 0.01) and allowed scientists to determine the most effective dose to be administered in phase III clinical trials, planned for early 1999.

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