The analysis of the repeated DBP measurements in the hypertension trial using a compound symmetry covariance pattern model gave a residual variance of a2 = 76 and the repeated measures had correlation p = 0.53 (see Section 6.3).

var j

We calculate the sample size required for a future study involving four post-treatment visits required to detect a difference in DBP of 5 mmHg at the 5% significance level with 80% power. The number of patients required per treatment group is n = 2(1.96 + 0.84)2x76 x (1 + 3x0.53)/(4x25) = 31.

Had no account been taken of the repeated measurements, then n would have been n = 2(zW2 + zpfo 2/A2 = 2(1.96 + 0.84)2 x 76/25 = 48.

If there is flexibility in the number of repeated measurements, then it might be worth calculating sample sizes for varying numbers of repeated measurements. For example, if 10 repeated measures were used, then n = 2(1.96 + 0.84)2 x 76 x (1 + 9x0.53)/(10x25) = 28.

However, this reduction in the number of patients required would be unlikely to justify the use of six additional repeated measures.

Was this article helpful?

0 0
Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment