Pb1 pb

The numerator of this expression gives us the odds of success on treatment A (i.e. the probability of success divided by the probability of failure). Similarly, the denominator is the odds of success on treatment B, leading to eb being the estimate of the OR.

Note that software packages vary in their parameterisations of the fixed effects and therefore care is needed to ensure the direction of effects is interpreted correctly. Calculation of ORs will be illustrated in the analysis of cold feet in the hypertension trial in Section 3.4.

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