The genome and forensic genetics

With advances in molecular biology techniques it is now possible to analyse any region within the 3.2 billion bases that make up the genome. DNA loci that are to be used for forensic genetics should have some key properties, they should ideally:

• be highly polymorphic (varying widely between individuals);

• be easy and cheap to characterize;

• give profiles that are simple to interpret and easy to compare between laboratories;

• not be under any selective pressure;

| A-type CCCTATCCA |j B-type CCCTCTCCA |j Other repeat variant

| A-type CCCTATCCA |j B-type CCCTCTCCA |j Other repeat variant

[] C-type CCCTGTCCA |j K-type CCCTAACCA

Figure 2.5 The structure of two MS1 (locus D1S7) VNTR alleles (Berg et al., 2003) [19]. The alleles are both relatively short containing 104 and 134 repeats - alleles at this locus can contain over 2000 repeats. The alleles are composed of several different variants of the 9 bp core repeat - this is a common feature of VNTR alleles

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