Neurobiological Theories Of Adhd

The overall pattern of neuropsychological, neuroimaging, and neurotransmitter-related findings in ADHD is consistent with the hypothesis that ADHD is associated with dysfunction in the frontosubcortical pathways mediated by catecholamine neurotransmission, which control attention and motor behavior. Dopaminergic, serotonergic, and noradrenergic systems have come under close scrutiny and each has contributed candidate genes for genetic analysis. Evidence to support dopaminergic dysfunction in...

References

Hyperkinetic children Aneuropsychosocial approach. In Kazdin AE, ed. Developmental clinical psychology and psychiatry, vol. 7. Beverly Hills, CA SAGE Publications, 1986 1-160. 2. Still GF. The Coulstonian Lectures on some abnormal psychical conditions in children. Lancet 1902 1 1008, 1077, 1163-1012, 1082, 1168. 3. Kahn E, Cohen LH. Organic driveness Abrain stem syndrome and one experience. N Eng J Med 1934 210 748-756. 4. Bradley C, Bowen M. School performance of...

Dopamine Hypofunction Hypothesis

Because the most effective treatment of ADHD involves the use of psychostimulant drugs, such as methylphenidate and d-amphetamine, which inhibit the dopamine transporter DAT and thereby increase the extracellular concentration of dopamine, ADHD symptoms have been suggested to result from hypoactivity of dopamine systems in the brain 13 . Results obtained with SHRs support this hypothesis. Low doses of d-amphetamine and methylphenidate reduced the hyperactivity of SHR and a stroke-prone...