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FIGURE 2.4 Immunoglobulin superfamily adhesion receptors.

FIGURE 2.3 Lymphocyte function-associated antigen-3.

and B lymphocytes point to a possible role in regulating the immune response.

Intercellular adhesion molecule-1 (ICAM-1) (Figure 2.8) is a 90-kDa cellular membrane glycoprotein that occurs in multiple cell types including dendritic cells and endothelial cells. It is the lymphocyte function-associated antigen-1 (LFA-1) ligand. The LFA-1 molecules on cytotoxic T lymphocytes (CTL) interact with ICAM-1 molecules found on CTL target cells. Interferon y tumor necrosis factor, and IL-1 can elevate ICAM-1 expression. ICAM-1 is a member of the immunoglobulin gene superfamily of cell adhesion molecules. It plays a major role in the inflammatory response and in T cell-mediated host responses serving as

FIGURE 2.5 CD2 ribbon diagram. Resolution 2.0 Ä.
FIGURE 2.7 CD2 ribbon structure.

Lymphocyte LFA-1 ICAM-1

Lymphocyte LFA-1 ICAM-1

Lymphocyte

Lymphocyte

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