Grey Matter Versus White Matter Ischemia

In addition to the size of the stroke, its location, and the relative involvement of gray versus white matter are key determinants of outcome. For example, small white matter strokes often cause extensive neurologic deficits by interrupting the passage of large axonal bundles such as those within the internal capsule. Blood flow in white matter is lower than in gray matter, and white matter ischemia is typically severe, with rapid cell swelling and tissue edema because there is little...

Mechanisms of Ischemic Cell Death

Mechanisms Ischemic Cell Injury

Ischemic stroke compromises blood flow and energy supply to the brain, which triggers at least five fundamental mechanisms that lead to cell death excito-toxicity and ionic imbalance, oxidative nitrative stress, inflammation, apoptosis, and peri-infarct depolarization Fig. 1.1 . These pathophysiological processes evolve in a series of complex spatial and temporal events spread out over hours or even days Major pathways implicated in ischemic cell death excitotoxicity, ionic imbalance, oxidative...