A2 Agonist

Several trials have evaluated the use of clonidine in reducing cardiac event rates in subsets of patients with known CAD undergoing vascular surgery. Clonidine has been shown to decrease the incidence of ischemia in a study of 297 patients undergoing vascular surgery (24% vs 39%) (Stuhmeier et al, 1996). In the European Mivazerol Trial (EMIT), mivazerol, an a-2 agonist not currently available in the United States, was studied perioperatively in 2,854 patients with known CAD or significant CAD risk factors undergoing noncardiac surgery (Oliver et al, 1999). No effect was found on the rate of perioperative MI; however, a statistically significant reduced rate of cardiac death was seen in patients undergoing both general and vascular surgery.

Overall, perioperative clonidine may have a similar effect on myocardial ischemia, infarction, and cardiac death as perioperative P-blockers, but further research is needed before its role in perioperative management can be fully elucidated.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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