A second drug, acamprosate (Campral), affects two other neurotransmitter systems that are known to be involved in the central nervous system effects of alcohol, (1) the y-aminobutyric acid system and (2) the glutamate system. It has been used for several years in Europe and was recently approved for use in the United States. Clinical studies there showed that approximately half of patients treated with acamprosate remained in remission after 12 weeks of medication compared with 26% on placebo. These rates are comparable to those observed with nal-trexone. Currently, the NIAAA is supporting a multicenter trial combining naltrexone with acamprosate to determine whether there may be an additive or synergistic effect because the drugs work on different neurotransmit-ter systems. Although not yet approved by the FDA, mul-tidrug therapy appears promising.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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