The I1307K mutation in the APC gene is present in 6% of the general Ashkenazi Jewish population, and in 10 to 15% of Ashkenazi Jews with CRC. Unlike other APC mutations, I1307K does not predispose to polyposis. Testing for the mutation is site-specific, with > 99% accuracy. For individuals with this mutation, biennial colonoscopy should begin at age 35 years, or 5 to 10 years before the earliest CRC diagnosis in the family, whichever is younger. If the tested individual does not have this mutation, and an affected family member has previously tested positive for this mutation, screening should follow general population screening guidelines. If the tested individual does not have this mutation, and no affected family member has been tested screening is based on family history.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

Get My Free Ebook

Post a comment