In a patient with decompensated cirrhosis, treatment can be extremely challenging with the risk of major adverse events (eg, severe thrombocytopenia, variceal hemorrhage, etc) and further decompensation (eg, worsening hepatic encephalopathy), and should therefore, be handled in liver transplant centers with the requisite experience and infrastructure, and preferably referred for clinical trials until the safety and efficacy data of treatment are established. However, patients with advanced bridging fibrosis or early cirrhosis (Child's class A) can often be treated in the community without major complications. The efficacy of treatment in patients with advanced fibrosis or compensated cirrhosis has been derived mostly from subgroup analysis of larger clinical trials, and suggests that the response is lower than in patients without cirrhosis. The main treatment option for such patients is liver transplant.
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Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.