Clinical Implications

The health care impact of chronic HCV infection appears to be increasing due to the increased prevalence of patients with infection for more than 20 years. Chronic HC infection is now estimated to be the leading cause of end-stage liver disease necessitating liver transplants in the United States.

However, in addition to progressive liver disease the potential health care impacts include HCC—it is estimated that chronic HC infection is associated with approximately 80% of HCC in the United States—and extrahepatic manifestations (eg, hematologic [cryoglobulinemia, aplastic anemia, thrombocytopenia, B-cell lymphoma], renal [glomerulonephritis, nephrotic syndrome], dermatologic [porphyria cutanea tarda, lichen planus, cutaneous necrotizing vasculitis], endocrine [diabetes mellitus, antithyroid antibodies], salivary [sialadenitis], and ocular [uveitis, corneal ulcer].)

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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