Hepatic Enzyme Inducers

Hepatic enzyme inducers including phenobarbital and rifampicin are used to manage patients with the pruritus of cholestasis. The reported ameliorating effect of the pruritus of cholestasis by phenobarbital is not sustained for a prolonged period of time. The risk and benefits of sedation have to be taken into account when prescribing this drug. Rifampicin has been used to treat the pruritus since the late 1980s. At doses between 300 to 450 mg/d or 10 mg/kg, rifampicin has been reported to improve the pruritus of cholestasis secondary to PBC as assessed subjectively. In one of the controlled studies, this drug appeared to be more effective than phenobarbital in inducing ameliorations of pruritus. The mechanism of the reported antipruritic effect of rifampicin is unknown. There are reservations to the use of rifampicin to treat patients with cholestasis and pruritus because of its potential for liver toxicity. Follow-up of liver tests is necessary if this drug is to be prescribed.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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