Hyperpigmentation

The skin of patients with cholestasis may darken. Hyperpigmentation is a classic finding in patients with PBC. The pigment is melanin. The etiology of the hyper-

TABLE 122-3. Selected Regimens for Vitamin Supplementation in Patients with Cholestasis and Vitamin Deficiencies

Deficient Dose/Mode of

Vitamin Preparation Administration/Frequency

A Vitamin A 30,000 IU/orally/3 times per week (105)

D Cholecalciferol 50,000 IU/orally/3 times per week (105)

E a-tocopherol 100 mg bid (105)

K Ki 10 to 10 mg SC daily for 3 consecutive days or monthly* (112)

bid = twice daily; SC = subcutaneously. *For patients who have chronic cholestasis.

pigmentation of cholestasis is not known. Increased availability of P-melanocyte stimulating hormone has been proposed as an etiologic factor in PBC. There are no treatments recommended for this complication.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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