The Food and Drug Administration has classified infliximab as pregnancy category B; however, animal reproduction studies have not been conducted as infliximab does not cross react with tumor necrosis factor (TNF)-a in species other than humans and chimpanzees. Toxicity studies have been conducted in mice using an analogous antibody with no evidence of maternal toxicity or teratogenicity. A safety database is maintained by Centocor (Malvern, PA). Outcomes data in direct exposure to infliximab report similar live births, miscarriage rates and therapeutic termination to the general population. Pharmacokinetics of this chimeric antibody to TNF-a suggests a 3 to 6 month washout period to ensure infliximab is no longer present in circulation.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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