Jimmy KoMD and Lloyd MayerMD

The practicing gastroenterologist is frequently confronted with immune-related diseases, such as Crohn's disease (CD), ulcerative colitis (UC), celiac sprue, and pernicious anemia (PA). However, the role of the gastrointestinal (GI) tract as the body's largest lymphoid organ is often overlooked. In fact, the surface area of the GI tract could cover two tennis courts, and within that surface is a rich supply of B- and T-lymphocytes, macrophages, and dendritic cells. The number of lymphocytes in the GI tract exceeds that in the spleen, but unlike other lymphoid organs, immune-associated cells in the GI tract are constantly confronted with antigen (mainly in the form of bacteria and food). Gut-associated lymphoid tissue, generally known as mucosa-associated lymphoid tissue (MALT), regulates immune responses in the gut to maintain homeostasis. Without this tight regulation, inflammation would predominate in the GI tract. Therefore, it is not difficult to imagine how disease can result in the GI tract when immune regulation is disrupted.

Why Gluten Free

Why Gluten Free

What Is The Gluten Free Diet And What You Need To Know Before You Try It. You may have heard the term gluten free, and you may even have a general idea as to what it means to eat a gluten free diet. Most people believe this type of diet is a curse for those who simply cannot tolerate the protein known as gluten, as they will never be able to eat any food that contains wheat, rye, barley, malts, or triticale.

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