Joseph R BloomerMD

The porphyrias are metabolic disorders which are characterized biochemically by the increased production, accumulation and excretion of porphyrins and/or porphyrin precursors, compounds which are intermediates of the heme biosynthetic pathway. The liver and bone marrow are the major sites of expression of the biochemical abnormality. The clinical manifestations are varied and include complications for which the gastroenterologist or hepa-tologist may be consulted for evaluation and management. principally these occur in patients with porphyria cutanea tarda, erythropoietic protoporphyria, and the acute (inducible) types of porphyria. Because there is a relationship between the clinical manifestations and biochemical abnormalities, the cornerstone of therapy is to use measures which will decrease the excess production and accumulation of the porphyrins and porphyrin precursors.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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