Kenneth W SchroederMD PhD and William J TremaineMD

Ulcerative colitis (UC) is a chronic inflammatory disease of unknown cause, which typically affects the rectum and variable areas of the proximal colon in a continuous pattern. There is no known cure but medications are often effective in controlling the inflammation and the associated symptoms. Based on the location and extent of the inflammation, the clinician can determine which medications may be expected to provide symptomatic benefit with a minimum of adverse effects. Hence, knowledge of the disease extent and severity of activity are critical to planning a medical therapy program.

When patients present with active symptoms, the primary initial goal is to alleviate the symptoms and induce remission. The secondary goal is to plan for a treatment program to maintain long-term remission. These two phases oftreatment may require a series of medications using different doses and routes of delivery, with a transition from induction of remission to maintenance of remission after the first few weeks.

ideally, any medical therapy should be evidence based (see Chapter 1,"Using Evidence-Based Medicine in Patient Care"). However most therapeutic trials, including those for UC, involve a single drug given at fixed dose for a short period of time and the trials do not address the changing needs of the patient over time, through the spectrum of changes in disease activity and extent. in reality, the best therapy for an individual patient with UC is based in part on evidence-based data and in part on anecdotal clinical experience. Depending on the unique circumstances for an individual patient, treatment of UC with either a sequential or combination therapeutic approach can be effective.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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