Mechanisms of Chronic Diarrhea in Diabetes Mellitus

Table 71-1 provides an overview of the pathophysiological mechanisms and conditions associated with diarrhea in diabetes. The mechanisms of chronic diarrhea in diabetes are incompletely understood. However, several commonly

Table 71-1 Mechanisms, Concomitant Conditions, and Clinical Characteristics of Diarrhea in Diabetes Mellitus

Pathophysiological Associated Mechanism Disease

Clinical Presentation

Exocrine pancreatic insufficiency Celiac sprue SB bacterial overgrowth Bile acid malabsorption

Diarrhea, steatorrhea

SB dysmotility Colonic dysmotility Decreased a-2-adrenergic tone in enterocytes

Constipation or diarrhea

Anorectal dysfunction Sensory neuropathy IAS-sympathetic EAS-pudendal neuropathy

Diarrhea or incontinence

SB = small bowel; IAS = internal anal sphincter; EAS = external anal sphincter.

encountered mechanisms for diarrhea in patients with diabetes should be considered. Diarrhea may result from intake of medications or the excessive use of dietetic foods that contain sorbitol as a sweetener. Autonomic neuropathy (Vinik et al, 2003) or diseases associated with diabetes, such as celiac disease, may be the underlying causes of chronic diarrhea.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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