Methotrexate (MTX) a folic acid antagonist is contraindi-cated before conception or during pregnancy. The drug is mutagenic and teratogenic with a high incidence of neural tube defects (Donnenfield et al, 1994). In male patients, MTX can produce oligospermia and chromosomal damage. If a patient has received MTX prior to attemting conception, folic acid should be prescribed (Narendranathan et al, 1989).

*Editor's Note: As mentioned, this issue is still controversial and most women want to stop the use of AZA/6-MP before conceiving. I share the author's view of staying on AZA, if needed, to maintain remission. To repeat, disease activity seemingly poses greater risks than immunomodular toxicity in most cases.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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