Orthotopic Liver Transplantation

For those patients whose poor underlying liver function and tumor number or location preclude hepatic resection, we advocate total hepatectomy with orthotopic liver transplantation (OLT). Although the initial series of OLT for HCC reported poor results, the selection criteria for OLT have subsequently undergone major revision, and more recent results have been favorable. Currently, patients with HCC and cirrhosis with three or less tumor nodules up to 3 cm in maximum diameter or a single tumor not exceeding 5 cm and no signs of vascular invasion should be considered for transplantation. Recent survival data obtained from Milan revealed 4-year survival rates of 75% in patients with solitary tumors that were less than 5 cm who had no vascular invasion (Mazzaferro et al, 1996). Many of the risk factors that predict cancer recurrence following OLT are similar to those that predict a high risk of recurrence after partial hepatectomy, with the major factor being the presence of vascular invasion.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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