Pathophysiology

Rational treatment for IBS is based on our understanding of its pathophysiology (Horwitz and Fisher, 2001). Motility dysfunction in the colon and, perhaps, the distal small intestine have long been considered important in the genesis of IBS-associated symptoms. A second pathogenetic mechanism may be visceral hypersensitivity whereby nonpainful intra-abdominal stimuli become painful (alldynia) or painful stimuli become more painful (hyperalgesia). Whether visceral hypersensitivity is due to hypervigilence or sensitization of sensory pathways by an acute event has not been determined. A third potential pathophysiologic abnormality in IBS is abnormal central processing of peripheral information as evidenced on proton emission tomography or functional magnetic resonance imaging. Although psychiatric factors are not considered to be the major cause of IBS, there is abundant evidence that psychological disorders are more common in patients with IBS when compared with either the general population or with medical control patients, such as those with inflammatory bowel disease. Recently, a role for infection in the genesis of IBS has been suggested. Many of the treatment modalities employed in the treatment of IBS target these putative pathogenetic factors (Creed et al,2001).

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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