Porphyria Cutanea Tarda Diagnosis

The major clinical feature in porphyria cutanea tarda (PCT) is fragility of sun-exposed skin which causes the formation of blisters and erosions after minor trauma, particularly on the backs of the hands. Chronic skin damage may lead to scarring and thickening of the skin which resembles scle-roderma. Skin lesions are accompanied by liver abnormalities which vary from mild portal inflammation to cirrhosis. In patients with long standing untreated PCT there is an increased incidence of hepatocellular carcinoma. Neurological symptoms do not occur in PCT. Alcoholism and use of estrogens are precipitating factors of PCT.

Patients also have an increased prevalence of chronic hepatitis C (HC) and mutations in the HFE gene which occur in hereditary hemochromatosis (Bloomer, 2000).

The diagnosis is established by demonstrating a marked increase in the excretion of octacarboxylporphyrin (uroporphyrin) and hepatcarboxyl porphyrin in the urine. In patients in whom the history indicates there is the familial form of PCT (10 to 20% of patients) the measurement of uroporphyrinogen decarboxylase activity in erythrocytes may also be used to establish the diagnosis.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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