Because there is little specific therapy for drug-induced liver disease, prevention is of great importance. This process starts during drug development. It is important to monitor for ALT abnormality, as well as signs and symptoms of liver disease, during clinical studies with new drugs. Even after a drug receives approval from the US Food and Drug Administration, surveillance and report of suspected cases should continue to identify hepatotoxicity that may not have been apparent during the initial clinical studies.

For patients who take drugs that are known to have hepa-totoxic potential, monitoring liver enzymes should be considered. Careful follow-up may identify emerging hepatotoxicity and, thus, prevent severe drug-induced liver disease. However, this approach is most rational for delayed-onset, idiosyncratic, drug-induced liver disease. When starting any drug, all patients should be educated about the signs and symptoms of liver disease and urged to report such symptoms to health care professionals immediately. This practice is particularly important for patients who take multiple medications because immune cross-sensitization has been known to occur among drugs in the same class, such as anticonvulsants, macrolides, or phe-nothiazines. If patients have a history of an immune hypersensitivity reaction to one drug, they may need to avoid other drugs from the same class.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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