Long term biochemical cure is difficult or impossible to achieve in patients with MEN I-associated gastrinoma. Almost all patients with MEN I will have recurrent disease and 10-year biochemical cures rarely occur. In contrast, 50% and 35% of sporadic gastrinoma patients undergoing surgical resection may be disease free at 5- and 10-year follow-up, respectively. Up to 93% of patients with MEN I-gastrinoma are alive 15 years after diagnosis, provided appropriate medical therapy is maintained. This, combined with the difficulty in achieving biochemical cure in MEN I has led some to conclude that aggressive surgical management should be reserved for the sporadic form.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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