There is a very strong epidemiologic link between H. pylori infection and the development of PUD. The proof that this association exists has been described following the observation that a significant proportion of patients with PUD have co-infection coupled with the observation that eradication strategies result in a significantly lowered risk for the development of PUD. Controversies exist as to whether H. pylori should be eradicated in patients who test positive for infection as a means of preventing the development of PUD. There is a greater likelihood for the development of PUD in patients who have coexistent H. pylori and NSAID usage. The treatment of H. pylori infection and the management of NSAID-induced ulcers are described in Chapter 23 "Helicobacter pylori and Gastroduodenal Disease"; Chapter 24 "Nonsteroidal Anti-Inflammatory Drugs and Gastrointestinal Complications"; Chapter 29, "Chronic Gastrititis"; and Chapter 33,"Primary Gastric Lymphoma."
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