Metastatic disease is the most common malignant process affecting the liver. Although metastatic disease can develop in the liver via systemic spread from most solid malignancies, certain tumor types have the propensity to develop liver-dominant disease and, often, isolated liver metastases. These include primarily colorectal cancer and, less commonly, neuroendocrine tumors, GI sarcomas, ocular melanoma, and others. There is a preponderance of uncontrolled studies strongly suggesting that surgical resection offers the best potential cure for colorectal cancer metastatic to the liver. Careful preoperative evaluation of the liver, primary tumor, and extrahepatic sites, is important to exclude unresectable disease and select those patients who may benefit most from resection. Potential strategies currently under investigation for improving outcomes include combining resection with adjuvant regional or systemic chemotherapy. For unresectable disease, other local ablative approaches, including RFA or regional chemotherapy may offer some benefit.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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