Summary

Gemcitabine is currently the only approved chemothera-peutic agent that has demonstrated significant antitumor effects in advanced PC. Although the efficacy of Gemcitabine may be augmented by innovative dosing schedules or by the use of synergistic drug combinations, the standard regimen to date remains single agent Gemcitabine. This strategy is also appropriate for patients with locally advanced disease, though these patients are commonly managed with combined modality approaches. Either a conventional 30-minute or fixed-dose-rate infusion is appropriate based on existing data. Combinations of Gemcitabine with other agents such as cisplatin, irinote-can, oxaliplatin, and fluoropyrimidines have not consistently resulted in significant improvement in survival or quality of life in studies available thus far and should not be considered the standard of care at the present time; however, this could change as the results of randomized studies are available. Given the data with conventional treatments, enrollment in a clinical trial should still be the preferred approach to these patients.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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