Summary

Much is rapidly changing in the landscape of the chemotherapeutic management for CRC. Current evidence supports the use of 5-FU/LV in combination with irinotecan or oxaliplatin as primary chemotherapy for reasonable performance status patients with unresectable advanced CRC. Capecitabine represents a more tolerable option for patients who would be candidates for palliative chemotherapy with 5-FU/LV alone. Regional chemotherapy strategies using HAI may be a consideration for selected patients with liver-limited metastatic disease. In the adjuvant setting, 6 months of 5-FU/LV remains the standard recommendation for patients with resected stage III disease and can be considered in select patients with stage II disease. This adjuvant standard may be revised to include combinations with either oxaliplatin or irinotecan pending the final results of several recent trials. Although current chemotherapy practices remain primarily defined by cytotoxic therapies, the future integration of targeted therapies holds the promise of further improving outcomes for patients with CRC.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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