Systemic Mastocytosis

In the 23 to 43% of patients with systemic mastocytosis, the diarrhea is mild to moderate in the majority, with > 90% having a stool volume < 1 L/d. In systemic mastocytosis, the primary cause of the most troubling diarrhea is gastric hypersecretion owing to hyperhistaminemia; therefore, it has a pathogenesis similar to that seen in patients with Zollinger-Ellison syndrome. However, villous atrophy and a secretory component, perhaps owing to prostaglandins,may be important diarrheal factors in some patients with systemic mastocytosis. The diarrhea in these patients is usually controlled by a combination of Hi and H2 receptor antagonists. The mast cell membrane-stabilizing drug cromolyn sodium (disodium chromoglycate) has been reported to be useful to treat diarrhea and other GI symptoms in a small number of patients with systemic mastocytosis. In patients with the malignant forms of mastocytosis, treatment with interferon alpha-2b, as well as chemotherapy and corticosteroids, has been used (Jensen, 2000).

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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