Are the results valid? Was the prognosis of patients in each group similar at the start of the trial? Did the investigators demonstrate similarity in all known determinants of outcome and did they adjust for any differences in the analysis? Were exposed patients equally likely to be identified in all groups being compared?
Was the prognosis of patients in each group similar after randomization? Were outcomes measured equally in the groups being compared? Was follow-up long enough and sufficiently complete? What are the results? How strong is the association between exposure and outcome? What is the precision of the estimate of risk? Can the results be applied to patient care? Were the problem and study patients similar to those in your practice? Was the duration of follow-up adequate? What is the magnitude of the risk? Should the exposure be intervened against?
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Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.