Church and colleagues (2003) randomized 247 patients presenting with severe peptic ulcer bleeding to heater probe (HP) plus thrombin injection or to HP plus placebo injection. Successful primary hemostasis was achieved in 97% of the patients. Recurrent bleeding developed in 15% of both groups. There was no difference in emergency surgery and mortality rates and there were no adverse events.

Kubba and colleagues (1996) randomized 140 patients to injection with epinephrine alone versus epinephrine combined with large doses of human thrombin (600 to 1000 IU). Only 4.5% of patients in the thrombin group experienced recurrent bleeding compared with 20% in the epinephrine group. Thus, thrombin had a significant benefit in arresting peptic ulcer bleeding.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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