Timothy J DavernMD

The clinical syndrome of fulminant hepatic (FHF) was originally defined by Trey and Davidson (1970)as the development of hepatic failure with encephalopathy within 8 weeks of the onset of symptoms and in the absence of preexisting liver disease. Although there have been subsequent refinements of this definition, with varying times from symptom onset to the development of hepatic encephalopathy, all have in common the presence of severe liver injury, hepatic encephalopathy, and the absence of preexisting clinically overt liver disease. FHF results from the abrupt loss of liver function secondary to severe injury from a variety of causes and is associated with a high mortality, predominantly from cerebral edema and infection. However, some causes of FHF are associated with a better prognosis than other forms. In general, the more rapid onset forms of FHF, for example, associated with acetaminophen hepatotoxicity, are associated with a higher incidence of cerebral edema but an overall better prognosis, probably reflecting the lack of liver architectural derangement and thus more favorable conditions for hepatic regeneration in these cases. In contrast, FHF due to idiosyncratic drug reactions, Wilson's disease, and of indeterminate etiology, which tend to follow a subacute course, carry a particularly poor prognosis.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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