Ursodeoxycholic Acid

Early enthusiasm for ursodeoxycholic acid (UDCA) was based on a report of some improvement observed in a small group of patients taking this relatively benign but expensive drug. A follow-up blinded clinical trial revealed no benefit of UDCA in a larger group of NASH patients (Lindor, 2003). Thus UDCA cannot be recommended as effective therapy for NASH.

This trial and trials by other investigators have recently shown that spontaneous improvement in NASH can occur without specific therapy once a diagnosis has been established. This observation is important in two respects. First is that it confirms the importance of conducting randomized placebo controlled trials to determine the efficacy of new agents in NASH. Second, it raises the important question of whether establishing the diagnosis of NASH (eg, performing a liver biopsy) provides enough impetus for lifestyle change such that patients commonly improve once a diagnosis is established. If true, this observation could provide an additional benefit of performing a liver biopsy when the diagnosis is suspected.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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