What is IM

IM distal to the gastric cardia is largely a consequence of H. pylori infection but other types of injury such as drugs may also result in IM. IM refers to the replacement of normal epithelium by intestinal-type mucosa. It parallels the severity of the associated gastritis in terms of its distribution. It may be more dominant in either antrum, body/fundus (oxyntic: acid-secreting mucosa) or the GEJ. Sometimes it may affect all three zones as a pangastritis. IM is associated with an increased risk of the intestinal type of gastric cancer (GC) epi-demiologically. This type of cancer accounts for approximately half of all cases. Diffuse cancer of the stomach accounts for the remainder. The diffuse type of GC, although also associated with H. pylori, does not have associated IM or dysplasia.

The sequence for the development of the intestinal type of GC is given below. Atrophic gastritis refers to a loss of gastric glands. Atrophic gastritis is present when IM replaces most of the gastric glands in a given biopsy down to the muscularis mucosae.

H. pylori ^ Gastritis ^ Atrophic Gastritis with IM ^ Dysplasia ^ Cancer.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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