• Age. Hand, foot, and mouth disease (Coxsackie virus A) affects both children and adults.
• Incubation period is unknown.
• Prodromal symptoms. Fever, headache, and malaise may accompany the rash.
• Initial rash. Initially there may be intense erythema surrounding yellow-grey vesicles 1-1-5 mm in diameter. These are mainly distributed on the palms and soles and in the mouth. Sometimes a more generalised eruption may develop.
• Development and resolution. Over three to five days the rash fades.
• Diagnosis. Coxsackie A (usually A16) virus is isolated from lesions and stools. A specific antibody may be found in the serum.
• Complications are rare but include widespread vesicular rashes and erythema multiforme.
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