The histopathologic features of LE specific skin disease include hyperkeratosis, epidermal atrophy, liquifactive vacuolar basal cell degeneration, and nodular perivascular and perifollicular mononuclear cell infiltrates. Some authors have reported degrees of LE specific features among LE subsets. SCLE has more epidermal atrophy, but less hyperkeratosis, basement membrane thickening, follicular plugging and inflammatory cell infiltrates when compared to DLE (Bangert et al. 1984; David-Bajar and Davis 1997). Since the histologic findings typically mirror the clinical findings, this is expected, and corresponds to the fine less adherent scale, lack of induration and less frequent alopecia of SCLE. Herrero et al biopsied the border of annular vesicular lesions in a SCLE cohort group with a high frequency of anti-Ro/SSA and the HLA DR3 phenotype (Herrero et al. 1988). Epidermal necrolysis was prominent and the authors suggested this immunophenotype may correlate with the histologic findings. However, other authors have reported variable success in differentiating LE subsets. Bangert et al. (1984) were unable to distinguish the histology between papulosquamous and annular SCLE lesions.

Table 2. Serological Findings in Patients with SCLE


Frequency range (percent)

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