David A. Sandham1 and Hans-J├╝rgen Pfannkuche2

'Global Discovery Chemistry, Horsham Research Centre, Wimblehurst Road, Horsham

RH12 5AB, UK

2Novartis Institutes of Biomedical Research, Gastrointestinal Diseases Area, Postfach,

CH-4002 Basel, Switzerland


1. Introduction 211

2. Prokinetic agent target classes 212

2.1. Dopamine D2 receptor antagonists 212

2.2. Serotonin 5-HT4 receptor agonists 213

2.3. Serotonin 5-HT3 receptor agonists 214

2.4. Cholecystokinin CCKa receptor antagonists 215

2.5. Motilin receptor agonists 216

2.6. m-opioid receptor antagonists 217

3. Conclusions 217 References 218

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