Genomic-based methodologies are increasingly used in drug development. The most-extensive applications have occurred in drug discovery due to advances in technologies that allow automated synthesis, analysis and for high-throughput screening against known targets. However, genomics can be used to identify previously uncharacterized pharmacologic actions. This tool provides the basis for the discovery and development of new classes of antifungal agents that should interfere with biological targets different to those described above. This could result in a wider chemotherapy agents armamentarium, which could be very useful to defeat fungal resistance [81-84].
Was this article helpful?